Apoptosis
Adenosine analog induced cell cycle arrest and apoptosis in leukemia HL-60 cells
Published in Cancer Weekly, November 1st, 2005
According to recent research from South Korea, "Human A3 adenosine receptor (A3 AR) agonists have been shown to play important roles in several physiological and pathological processes, including growth inhibition of human cancer cells. On this line, we recently found that a novel adenosine analog, 2-chloro-N-6(3-iodobenzyl)-4'-thioadenosine-5'-N-methyluronamide (thio-Cl-IB-MECA) was a potent human A3 AR agonist, and is superior to a known agonist Cl-IB-MECA [Jeong LS, et al. J Med Chem...
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Source: Cancer Weekly (2005-11-01)
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