Apoptosis
Motexafin gadolinium induces caspase-dependent apoptosis
Published in Cancer Weekly, November 1st, 2005
"Motexafin gadolinium (MGd, Xcytrin) is a tumor-localizing redox mediator that catalyzes the oxidation of intracellular reducing molecules including NADPH, ascorbate, protein and non-protein thiols, generating reactive oxygen species (ROS). MGd localizes to tumors and cooperates with radiation and chemotherapy to kill tumor cells in tissue culture and animal models," researchers in the United States reported.
"In this report, we demonstrate that MGd triggers the mitochondrial apoptotic pathway in the HF-1 lymphoma cell line as determined by loss of mitochondrial...
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Source: Cancer Weekly (2005-11-01)
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