Drug Metabolism
Glutathione trapping assay measures microsomal oxidation of furan in vitro
Published in Cancer Weekly, November 1st, 2005
"Furan is a liver carcinogen and toxicant," that is "oxidized to the reactive dialdehyde, cis-2-butene-1,4-dial, by microsomal enzymes," scientists in the United States explained. "This reactive metabolite readily reacts with glutathione nonenzymatically to form conjugates."
In a study conducted by L.A. Peterson and coauthors at the University of Minnesota, a "high-performance liquid chromatography-electrochemical method for the detection of cis-2-butene-1,4-dial-glutathione (GSH) conjugates in microsomal preparations was developed to measure the extent...
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Source: Cancer Weekly (2005-11-01)
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