Anticancer Drugs
TrxR inhibition contributes to cytotoxicity of anticancer compounds
Published in Cancer Weekly, November 1st, 2005
"Mammalian TrxR is important for cell proliferation, antioxidant defense, and redox signaling. Together with glutathione reductase (GR) it is the main enzyme providing reducing equivalents to many cellular processes," scientists in Sweden reported.
"GR and TrxR are flavoproteins of the same enzyme family, but only the latter is a selenoprotein. With the active site containing selenocysteine, TrxR may catalyze reduction of a wide range of substrates, but can at the same time easily be targeted by...
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Source: Cancer Weekly (2005-11-01)
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