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Prostate Cancer

Presence and specificity of tumor-associated lymphocytes analyzed

Published in Cancer Weekly, November 1st, 2005

Scientists analyzed the presence and specificity of tumor associated lymphocytes (TAL) from ascites fluid in prostate cancer.

According to recent research from Sweden, "We had the rare opportunity to study immunological responses of TAL from ascites fluid in a patient with hormone-refractory prostate cancer."

"We evaluated tumor antigen-specific T-cell responses, induced by either prostate specific antigen (PSA) pulsed dendritic cells (DCs) or PSA peptides, in TAL and peripheral blood lymphocytes. DC stimulation with PSA protein induced recognition of naturally processed PSA epitopes by both blood and ascites T cells. In contrast, only ascites T...

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