Tumor Suppression
Sequence of tumor suppressor inactivation influences tumorigenicity
Published in Cancer Weekly, November 1st, 2005
According to a study from the United States, "Malignant astrocytoma, the most prevalent primary brain tumor, is resistant to all known therapies and frequently harbors mutations that inactivate p53 and activate Ras signaling.
"We have generated mouse strains that lack p53 and harbor a conditional allele of the NF1 tumor suppressor that negatively regulates Ras signaling."
"The mice develop malignant astrocytomas with complete penetrance. The majority of tumors display characteristics of glioblastoma multiforme with concomitant alteration of signaling pathways...
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Source: Cancer Weekly (2005-11-01)
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