Tumor Suppressor Gene

ING4 suggested to be class II tumor suppressor gene in head and neck cancer

Published in Cancer Weekly, November 1st, 2005

Researchers suggested ING4 to be a class II tumor suppressor gene in head and neck cancer.

"We previously showed two members of the ING family, ING1 and ING3 as a tumor suppressor gene in head and neck cancer. Progress in human genome sequencing provided additional information of the new members of the ING family genes," scientists in Japan reported.

"ING4 is localized to chromosome 12p13.31 region and harbors the PHD domain highly homologous among ING family proteins. We analyzed loss of heterozygosity at 12p12-13 region in 50 head and neck squamous cell carcinomas by using 6 highly polymorphic microsatellite markers and found allelic loss in 66%...

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Source: Cancer Weekly (2005-11-01)

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