Published in Cancer Weekly, November 8th, 2005
"Histone deacetylases are important regulators of transcription and an emerging target for anticancer drugs. We present an overview over various assay formats that include radiolabeled histones, oligopeptides, and small molecules as substrates," scientists in Germany reported.
"The advantages and disadvantages of the various formats in terms of, e.g., substrate availability, throughput or subtype selectivity are discussed. Detailed procedures for various assay types that can be used for different problems, such as library screening or fluorescent inhibitor...
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