Cell Biology
Hepatitis C virus infection modifies THP-1 monocytoid cell behavior
Published in Cancer Weekly, November 15th, 2005
According to a study from Italy, "HCV is the main cause of hepatocellular carcinoma in industrialized countries. HCV-HIV-1 coinfection occurs frequently among users of illicit intravenous drugs, thereby increasing the severity of HIV disease and the evolution of chronic active hepatitis towards cirrhosis and hepatocellular carcinoma."
"The present work shows that THP-1 monocytoid cells are susceptible to HCV infection, of strain 1b, and that this strain can induce cellular modifications in this cell line. Infection of HCV was demonstrated by positivity for the E2 antigen...
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Source: Cancer Weekly (2005-11-15)
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