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Apoptosis

Anti-apoptotic and malignancy-causing protein Mcl-1 inhibited mitochondrial Ca2+ signals

Published in Cancer Weekly, November 15th, 2005

Scientists claimed anti-apoptotic protein Mcl-1 could inhibit mitochondrial Ca2+ signals.

According to recent research from the United States, "Apoptosis contributes to the regulation of cell growth and regeneration and to the development of neoplasia. Mcl-1 is an anti-apoptotic protein that is particularly important for the development of hematological and biliary malignancies, but the mechanism of action of Mcl-1 is unknown."

"A number of pro- and anti-apoptotic proteins exhibit their effects by modulating Ca2+ signals, so we examined the effects of Mcl-1 on components of the Ca2+ signaling pathway that are known to...

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