Genetics & Genomics

Increased genomic instability leads to higher cancer incidence in elderly

Published in Cancer Weekly, November 15th, 2005

Increased genomic instability leads to a higher incidence of cancer in the elderly.

"Advanced age is strikingly linked to increased incidence of cancer. To gain insight into the mechanism underlying the association between increased cancer incidence and aging in normal human physiological conditions, we used a case-control design and measured the mRNA expression levels of p53, ATM, hTERT and TRF2, the four major protectors of genomic integrity, in isolated peripheral blood lymphocytes from 202 confirmed bladder cancer (BC) patients and 199 healthy controls," scientists in the United States reported.

"Significant age effects on expression levels were...

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Source: Cancer Weekly (2005-11-15)

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