Breast Cancer

Phase II trial of combination therapy for advanced breast cancer underway

Published in Cancer Weekly, November 22nd, 2005

OncoGenex Technologies Inc. announced that the first patient has been treated in a phase II clinical trial of OGX-011 in combination with docetaxel in patients with advanced breast cancer.

OGX-011 is a second-generation antisense drug designed to specifically inhibit the production of clusterin, a cell-survival protein associated with resistance to standard anticancer treatments. This clinical trial is designed to assess the safety and efficacy of OGX-011 in combination with docetaxel in women with metastatic or locally advanced breast cancer. OncoGenex is developing OGX-011 in collaboration with Isis Pharmaceuticals Inc. (ISIS).

Increased clusterin...

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Source: Cancer Weekly (2005-11-22)

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