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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . November 29th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Apoptosis - Xanthohumol induced apoptosis in human colon cancer cells

Diagnostics - False positive lumpectomy margins for breast cancer caused by specimen compression

Diagnostics - Proteomic analysis differentiated varying forms of childhood leukemia

Diagnostics - Saturation biopsy predicted prostate tumor volume

Acute Myeloid Leukemia - Cell line OCI/AML3 appears to be a "remarkable" tool for biomolecular studies of NPMc+ AML

Adenosine Deaminase - Prognostic ability of adenosine deaminase activity studied

Adverse Drug Reaction - Magnesium supplementation mitigates cetuximab-induced hypomagnesemia

Anemia - Survey shows anemia untreated in many cancer patients

Antioxidants - Benefit of Crataegus aronia linked to three distinct processes

Apoptosis - 3-Hydrogenkwadaphnin induced apoptosis in human leukemia cell lines

Breast Cancer - Findings in breast cancer provide new insights

Apoptosis - Apoptosis-related residues in human thymosin beta-10 identified by mutational analysis

Apoptosis - Basic biology of apoptosis and implications for pediatric surgery reviewed

Apoptosis - Effects of combining a p38 MAPK inhibitor with an antioxidant studied

Apoptosis - Hsp90 inhibitors induced apoptosis of ZAP-70 and chronic lymphocytic leukemia

Breast Cancer - Research in breast cancer provides new insights

Apoptosis - Mechanism of chronic lymphocytic leukemia cell death in response to flavopiridol described

Apoptosis - NF-kappa B inhibitor enhances TPA-induced growth inhibition and apoptosis in myeloid leukemia cells

Apoptosis - Retinamide-induced apoptosis in glioblastomas linked to down-regulation of anti-apoptotic proteins

Apoptosis - TRAIL-mediated apoptosis enhanced by amiloride

Apoptosis - Xanthohumol induced apoptosis in B-chronic lymphocytic leukemia cells

Barrett Esophagus - Aspirin and similar drugs may reduce the risk of esophageal cancer in people with Barrett esophagus

Breast Cancer - Studies describe new findings in breast cancer research

Bladder Cancer Risk Factors - 4,4'-Methylenebis(2-chloroaniline) increases risk of bladder cancer

Bone Cancer - Researchers detail new studies and findings in the area of bone cancer

Brain Cancer - NDA submitted in Japan for temozolomide capsules to treat malignant glioma

Brain Cancer - Role of calmodulin-dependent phosphodiesterase in human brain tumors reviewed

Breast Cancer - Advanced local disease may predict distant metastases for premenopausal women

Breast Cancer - Annexin A8 expression has significant impact on invasive carcinoma outcome

Cancer Therapy - New data illuminates research in cancer therapy

Breast Cancer - Case definition approach is proposed to define cancer-related fatigue syndrome

Breast Cancer - Chest wall resection for recurrent breast cancer can provide long-term palliation

Breast Cancer - Data advance knowledge in breast cancer research

Breast Cancer - Data confirm combination therapy improves breast cancer survival in fit women

Breast Cancer - Differential gene expression occurs after chromosome transfer into breast cancer cells

Breast Cancer - Dual cancer-specific targeting cures primary and distant breast carcinomas

Cancer Therapy - Researchers describe findings in cancer therapy studies

Breast Cancer - EphA2-deficiency blocks tumor angiogenesis and metastatic progression in mice

Breast Cancer - Fats and fatty acids are not associated with increased risk of breast cancer

Breast Cancer - Knowledge about consuming soy food would benefit women at risk for breast cancer

Breast Cancer - Mammaglobin is a serum marker for breast cancer

Breast Cancer - Metaplastic breast cancer and adenocarcinoma should have similar treatment plans

Cancer Therapy - Studies add new findings to cancer therapy body of knowledge

Breast Cancer - PACS breast imaging system enables mobile digital mammography in Australia

Breast Cancer - Sonography helps identify pathologic breast conditions in children and adolescents

Breast Cancer - U.S. FDA grants approval to market tamoxifen oral liquid for breast cancer

Breast Cancer Diagnosis - Detection method for identifying breast cancer is prognostically important

Leukemia - Researchers' findings advance leukemia research

Breast Cancer Diagnosis - MRI contralateral breast screening reveals occult breast cancer

Breast Cancer Diagnosis - Sentinel lymph node dissection skills of surgeons verified through clinical trial

Breast Cancer Diagnosis - Sonographically guided needle biopsy provides additional diagnostic assistance

Breast Cancer Risk Factors - Breast cancer risk is not associated with intrauterine levonorgestrele

Breast Cancer Risk Factors - Estrogen-plus-progestin use increases mammographic density in postmenopausal women

Breast Cancer Risk Factors - Inverse association found between dietary lignan intake and breast density

Oncology - Research in oncology provides new insights

Breast Cancer Screening - CAD company, university medical center bring mammovan to Washington, DC-area communities

Breast Cancer Screening - Sonography in conjunction with mammography may enhance diagnosis of malignancy

Breast Cancer Survival - Increased vegetable and fruit intake positively impacts breast cancer survival

Breast Cancer Treatment - Adjuvant chemotherapy is not associated with improved survival in women aged 70

Breast Cancer Treatment - Breast MRI encouraged for women considering breast conservation therapy

Breast Cancer Treatment - Extracapsular spread does not identify patients benefited by radiotherapy

Oncology - Researchers report details of new studies and findings in the area of oncology

Breast Cancer Treatment - Quality of life not adversely affected by letrozole after tamoxifen therapy

Breast Cancer Treatment - Racial disparities uncovered in treatment among women with breast cancer

Breast Cancer Treatment - Study shows benefit from sentinel lymph node mapping prior to salvage mastectomy

Breast Cancer Vaccine - Aromatase inhibitors increase tumor sensitivity to cytotoxicity

Breast Cancer Vaccine - Fusion to listeriolysin O enhances immunogenicity of HER-2/neu

Business & Finance - Clinical-stage pharmaceutical company files $50 million shelf registration statement

Oncology - Studies advance knowledge in oncology research

Business & Finance - Maker of cancer therapy systems reports growth in FY 2005 net earnings, revenues

Business & Finance - Men's health company reports third-quarter net loss of $9.9 million

Business & Finance - Report predicts $1.5 billion in drug sales of treatment for chemo side effects

Business & Finance - Spanish biotech company reports R&D spending up by 10%

Business Update - Cancer diagnostics company changes name

Cancer Care - Cancer survivors require tailored follow-up plans and new clinical guidelines

Cancer Diagnostics - Agreement signed to codevelop noninvasive cancer diagnostic technology

Cancer Pain Management - Administration of S(+)-ketamine for neuropathic cancer pain requires further study

Cancer Pain Management - Cancer pain experience of Israeli adults 65 years and older needs further study

Cancer Pain Management - Oral and rectal tramadol relieved pain in opioid-naive cancer patients

Cancer Pain Management - Pain management improved quality of life in abdominal cancer patients

Cancer Research - Quaking gene likely suppresses tumor growth, researchers report

Cancer Research - Study implicates viral-mediated cell fusion as a possible engine of cancer formation

Cancer Risk Factors - Cigarette smoking linked to colorectal polyp recurrence

Cancer Risk Factors - Deep glandular extension of carcinoma in situ linked with highest risk of early recurrence

Cancer Risk Factors - Dual association of beta-carotene intake seen with risk of tobacco-related cancers

Cancer Risk Factors - Elevated risk of second cancer after breast cancer may justify screening

Cancer Risk Factors - Family history linked to lung cancer risk

Cancer Risk Factors - IL-8 -251T allele was associated with increased risk of gastric carcinoma in Chinese

Cancer Risk Factors - Link between performance-enhancing supplement use and testicular cancer risk examined

Cancer Risk Factors - Paradigm shifts in radiation biology shed new light on radiation-induced disease

Cancer Risk Factors - Post-traumatic stress identified in high-risk women with familial cancer risk

Cancer Risk Factors - Supplement use among men with prostate cancer tracked

Cancer Risk Factors - Testicular cancer therapy eliminated as risk factor for erectile dysfunction

Cancer Therapy - Anticoagulants stifle angiogenic growth factor and solid tumor progression

Cancer Therapy - Antisense oligonucleotide to clusterin evaluated for prostate cancer

Cancer Therapy - Carcinoma cells with impaired cyclooxygenase-2 are radiation sensitive

Cancer Therapy - Chemotherapy-induced malformations in utero may be related to age during exposure

Cancer Therapy - Chromosome breakpoints in neuroblastoma at sub-kilobase resolution revealed

Cancer Therapy - Data advance knowledge in cancer therapy research

Cancer Therapy - EB1 may activate beta-catenin/TCF pathway in esophageal squamous cell carcinoma

Cancer Therapy - Gene delivery may be an effective therapy for hepatoma

Cancer Therapy - Guidelines for Sertoli cell tumor of the testis in children needed

Cancer Therapy - Human telomerase reverse transcriptase gene may be therapeutic in bladder cancer

Cancer Therapy - IL-2 and histamine dihydrochloride assessed in renal cell carcinoma patients

Cancer Therapy - INGN 241 cancer therapy inhibits tumor angiogenesis

Cancer Therapy - Intermediate doses of interferon alfa 2b did not improve outcome for melanoma patients

Cancer Therapy - Metastatic gastrointestinal stromal tumors treated with imatinib and resection

Cancer Therapy - Neuroprotection with amifostine from platinum/taxane-based chemotherapy requires further study

Cancer Therapy - Oncolytic reovirus safe and effective against liver metastasis from pancreatic cancer

Cancer Therapy - Optimal duration of neoadjuvant hormonal therapy is longer than 3 months

Cancer Therapy - Phase I clinical trial in prostate cancer initiated with monoclonal antibody AGS-PSCA

Cancer Therapy - Postoperative chemoradiotherapy used to treat locally advanced rectal cancer

Cancer Therapy - Radiation-enhanced vascular endothelial growth factor may cause radioresistance in glioblastomas

Cancer Therapy - Sentinel lymph node dissection adequately managed lobular breast cancer

Cancer Therapy - Suicide gene expression may be useful in deletion of tumorigenesis

Cancer Therapy - Surgeons' therapeutic preferences for occult breast cancer surveyed

Cancer Therapy - Timely withdrawal of G-CSF reduced occurrence of thrombocytopenia during dose-dense chemotherapy

Cancer Therapy - Two different physiotherapy methods compared as treatment for lymphedema after breast surgery

Cancer Therapy - U.S. FDA grants orphan-drug designation for Zactima

Cancer Therapy - Use of estramustine, vinorelbine, and mitoxantrone for hormone-refractory prostate cancer deemed feasible

Cancer Therapy - YM529 may inhibit cancer cell invasion into the bone matrix by repressing the expression of CXCR-4

Cancer Therapy - Young scientists develop gel to help doctors target cancer tumors more efficiently

Cancer Vaccine - Cytokines enhance vaccine effects of heat shock protein 70-rich tumor cell lysate

Cancer Vaccine - Dendritic cells differentiated with IFN-beta and IL-3 induce potent CD8+ T cell response

Cancer Vaccine - Design of cancer vaccines must consider tumor stage

Cancer Vaccine - Development of dexosomes as therapeutic cancer vaccine outlined

Cancer Vaccine - Exosomes show potential in immunotherapy of cancer

Cancer Vaccine - Fusion protein vaccine generates potent antitumor effects

Cancer Vaccine - RAFT scaffolds look promising for developing anticancer vaccines

Cancer Vaccine - Virions expressing MAGE-A1 epitope show promise as target for cancer immunotherapy

Cancer Vaccine - Virulizin activates NK cells through IL-12 expression in macrophages

Carcinogenesis - Akt-mTOR tango related to cancer progression

Carcinogenesis - Beta-catenin prevents nitric oxide-induced apoptosis in colonic cancer cells

Carcinogenesis - Candidate tumor suppressor gene ZAC involved in etiology of basal cell carcinomas

Carcinogenesis - Misregulation of P13-K pathway in centroacinar cells may contribute to pancreatic carcinoma

Cardiology - Company studies FX06 for heart muscle inflammation following MI treatment

Cervical Cancer - Digital camera assessment may be a useful tool for cervical neoplasia detection

Cervical Cancer - HPV DNA testing shows promise to improve cervical cancer screening and testing

Cervical Cancer - Lymph node metastases predicted by measurement of squamous cell carcinoma antigen

Cervical Cancer - Researchers' work adds to cervical cancer body of knowledge

Cervical Cancer Vaccine - HPV vaccine offers best strategy for preventing cervical cancer in developing countries

Cervical Cancer Vaccine - Strategies to prevent cervical cancer by HPV vaccination are presented

Cervical Cancer Vaccine - Vaccine encoding chimeric hepatitis-HPV proteins enhances antibody and T-cell responses

Chemotherapy - Gemcitabine has a tumor ablative effect when given intravesically for bladder cancer

Chemotherapy - Irinotecan plus cisplatin did not confer benefits over cisplatin alone for treatment of lung cancer

Chemotherapy - Retinoid/arsenic combination therapy used to treat acute promyelocytic leukemia

Chemotherapy - Uracil and tegafur plus gemcitabine chemotherapy used to treat lung cancer

Clinical Trials - Abraxane studies show high response rates in variety of tumors

Clinical Trials - Clinical endpoints of equivalency met in phase III trial of fibrin sealant system

Clinical Trials - Patterns of participation and patient recruitment in clinical trials assessed

Clinical Trials - Update shows sorafenib tosylate effective treatment for advanced kidney cancer

Collaborations - Agreement signed with Baylor Health Care System for breast cushion

Collaborations - Alliance to focus on production of a protein targeting cancer

Collaborations - Cancer alliance to collaborate on research into solid tumor treatment

Collaborations - Collaboration inked to develop and market ATryn in Europe, Middle East, and Canada

Collaborations - Companies reach mutual decision to dissolve agreement on anticancer product

Collaborations - Deal signed with AstraZeneca to develop prostate cancer treatment

Collaborations - Partnership forged to develop new cancer diagnostics

Collaborations - Partnership to focus on clinical drug response prediction platform for cancer drug development

Collaborations - Pharma company announces agreement to promote anti-nausea drug

Collaborations - Strategic alliance and supply agreement signed for listeria cancer vaccines

Colon Cancer - Ig-4-1BB ligand-IL-12 gene combination eradicates hepatic colon carcinoma

Colorectal Cancer - Resection of liver metastases safer and more effective than cryoablation

Colorectal Carcinoma - OXXEL regimen is safe and effective treatment for metastatic corectal carcinoma

Complementary & Alternative Medicine - Hypothesis that CAM users are more autonomous problem solvers and decision-makers not supported

Complementary & Alternative Medicine - Oral curcumin may benefit patients with cancers of the gastrointestinal tract

Complementary & Alternative Medicine - Physicians need to assess patients' use of complementary and alternative medicine

DNA Vaccine - DNA-encoded TLR agonist expression provides options for DNA vaccines

DNA Vaccine - Method to deliver plasmid DNA into cell nucleus developed

DNA Vaccine - Survival gene Bcl-xl potentiates DNA-raised antitumor immunity

Dendritic Cell Vaccine - Dexosomes from dendritic cells are source of variability in MHC class II response

Dendritic Cell Vaccine - New viral system for generating antigen-specific T cells developed

Diagnostic Imaging - Voxel analysis of dynamic contrast-enhanced MRI assesses tumor response to antiangiogenic therapy

Diagnostics - Axillary lymph node status of breast cancer patients predicted by biology of primary tumor

Diagnostics - CT features of pulmonary inflammatory pseudotumor described

Diagnostics - Cheek cells used to identify lung cancer

Diagnostics - Ferucarbotran used to detect bone marrow tumors in rabbit model

Diagnostics - Intrahepatic bile duct dilatation indicated early-stage intrahepatic cholangiocarcinoma

Diagnostics - License agreement inked with Genzyme for lung cancer-associated genes

Diagnostics - Molecule imprinting-chemiluminescence method used to determine tamoxifen in breast cancer sufferers' urine

Diagnostics - New stool tests for colorectal cancer screening evaluated

Diagnostics - Novel interpretation strategy distinguished pulmonary squamous cell carcinoma as metastasis or second primary

Diagnostics - Positron emission tomography identified radiation-induced lung injury

Diagnostics - Predictive nomogram models for nonsentinel node metastasis evaluated

Diagnostics - Prostate cancer detected in men with serum PSA concentration of 2.0-4.0 ng/mL

Diagnostics - Proton magnetic resonance spectroscopy offers biochemical monitoring of residual neuroblastoma

Diagnostics - Researchers publish new studies and findings in the area of diagnostics

Diagnostics - Salivary microbiota used as diagnostic indicator of oral cancer

Diagnostics - Tissue compression deemed unnecessary for needle-localized breast lesion identification

Diagnostics - Transbronchial biopsy used to diagnose lung cancer

Diagnostics - Utility of extracapsular spread as an indicator for axillary irradiation assessed

Diet & Nutrition - Case of nutritional treatment for cancer reported

Diet & Nutrition - Clinical-based intervention improved diet in patients with head and neck cancer

Diet & Nutrition - Researchers' work adds to diet & nutrition body of knowledge

Diet & Nutrition - Strategies for treating anorexia and cachexia in gastrointestinal cancer outlined

Disease Associations - CTLA4high genotype associated with myasthenia gravis in thymoma patients

Disease Associations - Kaposi sarcoma-associated herpesvirus has immediate, early trans-inducing function

Disease Associations - Osteonecrosis of jaw observed in patient with hormone-refractory prostate cancer

Disease Associations - Risk of second cancer after hospitalization for venous thromboembolism analyzed

Disease Control - Morphine public health program offers cancer and AIDS pain relief in sub-Saharan Africa

Drug Delivery - Local delivery of IL-2 and adriamycin has synergistic effects

Drug Delivery - Novel assay measures bioavailable liposomal doxorubicin in tumors

Drug Development - AS1404 selectively disrupts tumor blood vessels while leaving those in healthy tissues unharmed

Drug Development - Antiangiogenic strategies aimed at normalizing the tumor vasculature may be successful

Drug Development - Ascorbic acid intake killed cancer cells

Drug Development - CNTO 95 abates tumor angiogenesis without harming physiological neovascularization

Drug Development - Newly synthesized 1,2,4-triazol-3-one derivatives showed antitumor activity

Drug Development - Nexavar (sorafenib tosylate) tablets chosen as trade name for investigational cancer treatment

Drug Development - Oncology product candidates acquired from Genencor

Drug Development - Studies describe new findings in drug development research

Drug Development - Vitamin E amides demonstrated enhanced proapoptotic activity

Drug Resistance - MDR1 expression involved in Imatinib resistance

Drug Resistance - Transient hypoxia augments tumor sensitivity to topotecan

Drug Safety - Antineoplastic drug contamination posed occupational hazard in a Swedish hospital pharmacy

Ductal Carcinoma in Situ - Highest detection rate of DCIS achieved with mapping technique for breast MRI

Endometrial Cancer - Physicians urged to assess adnexa in premenopausal women with endometrial cancer

Endometrial Cancer - Researchers explore controversies concerning radiotherapy in endometrial cancer

Enzymology - Telomerase catalytic subunit sequences are needed for transcriptional activity

Epidemiology - Mucocutaneous infections are more frequent and severe in primary immunodeficiencies

Epstein-Barr Virus - Low-dose chemotherapy effective in children with EBV+ post-transplantation disease

Eye Cancer - Visual acuity preserved after Ruthenium-106 brachytherapy of choroidal melanomas

Facilities - Maker of seeds for brachytherapy to open new production facility in Washington

Finance - Biopharma company announces 22% increase in sales for third quarter

Finance - Biopharma company reports net loss of $34.7 million

Finance - Biotech company reports $79.6 million GAAP net loss in third quarter

Finance - Cancer diagnostics company reports increased third quarter revenues of $2.78 M

Finance - Clinical-stage pharmaceutical company reports third-quarter revenue of about $1,250,000

Finance - Computer-aided detection developer begins clinical studies program in China

Finance - Medical device company reports revenues of $11.2 million for third quarter

Finance - Pharma company reports net loss of $22.6 million

Finance - Pharma company reports net loss of $3.4 million for 3 months

Finance - Pharma company reports net loss of approximately $10.5 million

Finance - Pharmaceutical company announces net loss of $20.0 million

Finance - Provigil maker reports strong growth in third quarter; revenue up 18%

Finance - RNAi-focused company reports net loss of eight cents per share of common stock

Finance - Radiation therapy provider reports total third quarter revenue of $56.0 million

Finance - Tolamba maker announces third-quarter revenues of $0.4 million

Finance - U.S. Oncology reports expected third quarter revenues of $640-650 million

Gastric Cancer - Laparoscopic distal gastrectomy with regional lymph node dissection safe and effective

Gastroenterology - Fas/CD95 relays outcomes after hepatic resection for metastatic colorectal cancer

Gene Research - Epidermal growth factor receptor gene mutations govern lung cancer pathogenesis

Gene Research - International consortium completes catalog of human genetic variation

Gene Therapy - Fractalkine gene therapy for neuroblastoma is more effective with interleukin

Genetics & Genomics - Biomedical and health applications are boosted by results of industry and academic collaboration

Genetics & Genomics - Chromatin signaling during skeletal myogenesis presents targets for gene expression

Genetics & Genomics - Genomic instability assessment with array-CGH improves prognostic accuracy

Genetics & Genomics - Nonsense termination can be suppressed using antisense agents

Genetics & Genomics - Section E6 of ACMG technical standards/guidelines designed as educational resource

Genetics & Genomics - Single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes identified

Genetics & Genomics - Subtle gene expression changes detected in T cells during anti-tumor response

Geriatrics - Steps needed to improve opportunities for earlier admission of elderly surgical patients

Glioblastoma - Outcomes of newly diagnosed glioblastoma patients in Lombardia followed trends of other case series

Glioblastoma - Tumor's molecular signature could identify patients likely to respond to drug treatment

Glioblastoma Multiforme - FDA approval summary for temozolomide plus radiation for glioblastoma multiforme released

Gynecological Cancer - Multidisciplinary approach needed for premenopausal women with gynecologic cancer

Gynecology - Vascular endothelial growth factor Trap and paclitaxel combine to treat ovarian cancer in mice

HIV/AIDS Healthcare - HIV+ and immunodeficient children can safely attend a properly staffed camp

HIV/AIDS-Related Kaposi Sarcoma - Kaposi sarcoma therapy in HIV/AIDS focuses on long-term tumor control

HIV/AIDS-Related Lymphoma - Chemotherapy and HSCT for HIV-associated lymphoma patients on HAART does not worsen immune defects

Head & Neck Cancer - Antiangiogenic agents enhance nasopharyngeal carcinoma responsiveness to photodynamic therapy

Hematology - Cytokine polymorphisms are not associated with chronic idiopathic neutropenia

Hepatitis B Virus - E-cadherin expression represses via activation of DNA methyltransferase 1

Hepatitis B Virus - Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues

Hepatocellular Cancer - Protein amounts vary in hepatocellular carcinoma in hepatitis C patients

Human Papillomavirus - HPV in HIV-positive women is unrelated to occurrence of cervical dysplasia

Human Papillomavirus - Vaccines are needed to prevent genital infection with HPV in adolescents

Human Papillomavirus Vaccine - DNA vaccines based on chimeric potyvirus-like particles carrying HPV16 E7 peptide developed

Human Papillomavirus Vaccine - HPV L1L2-E7 virus-like particles elicit T-helper responses in cervical cancer

Human Papillomavirus Vaccine - Model for vaccination against multiple HPV types developed

Imaging - Gene expression profiling can direct molecular imaging of lung cancer

Imaging - MRI and CAD companies partner to integrate systems for breast imaging technology

Imaging - PET + FDG underutilized for diagnosis and treatment female reproductive organ cancer, study says

Immunology - Modifying immune system response to chemotherapy could lead to new treatment approaches

Immunotherapy - Clinical trials are underway to enhance immune systems of breast and colorectal cancer patients

Influenza Vaccine - Vaccination for influenza in children with cancer is safe and immunogenic

Information Technology - Clinical software incorporates U.S. National Cancer Institute reports

Kaposi Sarcoma - Kaposi sarcoma developed secondary to tuberculosis in HIV-uninfected patient

Leukemia - Gastrin-gastrin receptor axis appears to be a potential target for leukemia therapies

Leukemia - Researchers' data advance leukemia research

Leukemia - U.S. FDA approves Arranon Injection

Leukemia Vaccine - Responses to CD40 ligand/IL-2 autologous cell vaccine transient

Liver Cancer - New alpha-fetoprotein-derived epitope in liver cancer identified

Lung Cancer - Fewer black patients opt for lung cancer surgery than white patients

Lung Cancer - Minimally invasive surgery may increase options for elderly patients with some lung cancers

Lung Cancer - Researchers publish new studies and findings in the area of lung cancer

Lung Cancer - Study shows lung cancer survival better in women than men

Lung Cancer Vaccine - BLP25 liposome vaccine may extend survival in non-small-cell lung cancer

Lung Cancer Vaccine - Bec2/BCG adjuvant vaccine had no effect in patients with lung cancer

Lymphoma Vaccine - Oncolytic measles virus in cutaneous T-cell lymphomas mounts antitumor immune responses

Medical Devices - Chronic indwelling pleural catheter enables effective outpatient management

Medical Devices - Development of user- and patient-friendly endorectal balloons warranted

Medical Devices - Modified mass spectrometer identifies diseased areas of liver tissue

Medulloblastoma - Ink4c and Ptch1 genes collaborate to suppress medulloblastoma, investigators find

Melanoma - Occupational risks of melanoma identified in female Swedish population

Melanoma - Ocular melanoma metastasized to kidney 20 years after initial diagnosis

Melanoma - P-cadherin counteracts invasion in human melanoma

Melanoma Vaccine - IL-21 influences frequency, phenotype, and affinity of antigen-specific CD8 T cell response

Meningioma - HU/radiation combination is effective for progressive or recurrent meningioma

Mental Health - Mental health services are underutilized by patients with advanced cancer

Mergers & Acquisitions - Acquisition of Greenwhich Therapeutics raises $8.4 million in private placement

Mergers & Acquisitions - Letter of intent executed for acquisition of Gastrotech Pharma

Microencapsulation - HER-2/neu peptide with PLA microspheres induces Th1 immune response

Myelodysplastic Syndrome - Vitamin D2 analog not effective for treatment of myelodysplastic syndrome

Nanotechnology - Poly(amidoamine) dendrimer-based nanodevice developed for cancer therapy

Neuroscience - Celecoxib curtails meningioma cell growth

Neuroscience - Contortrostatin stops glioma tumor progression and prolongs survival in rodent models

Obesity - Treatment complications for gynecologic cancers are increased due to obesity

Oncology - Cellular cross-talk fosters neuroblastoma differentiation and angiogenesis inhibition

Oncology - Cyclooxygenase-2 drives histamine-induced cancer proliferation

Oncology - Dasatinib may be valuable therapy for patients with epithelial tumors

Oncology - Fibroblast labeling helps track tumor vessel growth and maturation

Oncology - Gamma secretase inhibitor blocks Notch activation and induces apoptosis in KS tumor cells

Oncology - Mast cell heparin uses fibroblasts to staunch tumor cell growth

Oncology - Pretreatment vascular endothelial growth factor profiles metastatic non-small cell lung cancer

Oncology - Reports add new data to oncology research

Oncology - Risk of lymphohematopoietic malignancies is relatively unrelated to body size

Oncology - Serum factors predict neoangiogenesis in canine lymphoma models

Oncology Care - Oncology alliance launches study of supportive care guidelines

Oral Health - Osteoclast-related cytokines promote mandibular invasion by squamous cell cancer

Ovarian Cancer - Clinical data on thalidomide reported in recurrent epithelial ovarian cancer

Ovarian Cancer - Ovarian cancer risk is not increased for women from hereditary breast cancer families

Pain Management - Fentanyl patch is a safe alternative to oral opioids for pediatric pain patients

Palliative Care - Palliative care should be tailored to problems experienced by cancer patients

Palliative Care - Palliative care's goal is humanization of terminal cancer

Pancreatic Cancer - Trial shows Xeloda with standard chemo extends survival in pancreatic cancer

Pancreatic Cancer - U.S. FDA approves Tarceva in combination with gemcitabine chemotherapy for pancreatic cancer

Patents - Biotech company receives notice of a U.S. patent allowance for targeted immunotherapy

Patents - Vascular targeting agent developer granted patent for anticancer compounds

Pediatric Cancer - Childhood recurrent ependymomas treated with oral etoposide therapy

Pediatric Oncology - Histone deacetylase inhibitor may induce differentiation of neuroblastoma cells

Pediatric Surgery - Propofol offered quicker sedation but linked to higher rate of side effects

Personnel - Bruce D. Broussard named president of cancer treatment, support services network

Personnel - Dr. Ronald M. Lindsay joins board of directors of quantitative diagnostics company

Personnel - Pharma company appoints Guillermo A. Herrera as CEO, president and director

Personnel - Richard G. Pestell named director of the Kimmel Cancer Center

Personnel - Staff reductions announced by cancer-focused pharmaceutical products company

Pharmaceutical Research - Diabetic retinopathy therapy may treat other angiogenesis-dependent diseases

Polyomavirus Diagnostics - Real-time PCR assay rapidly quantitates human polyomaviruses

Product Licensing - Testing company licenses technology for cancer of unknown primary origin

Prognostics - Clinicopathologic features, classification, and prognostic factors of B-cell lymphomas discussed

Prognostics - Detection of tyrosine hydroxylase in patients with advanced neuroblastoma predicted worse prognosis

Prognostics - Extent of surgical margin positivity correlated with prostate specific antigen recurrence

Prognostics - Factors that predict recurrence of hepatocellular carcinoma identified

Prognostics - General prognostic models underestimated mortality risk in critically ill cancer patients

Prognostics - LAMP3/TSC403/DC-LAMP overexpression promotes metastasis in cervical cancer

Prognostics - Monosomy 3 can predict death but not time until death in choroidal melanoma

Prognostics - Myeloid antigen expression did not prognosticate high-risk acute lymphoblastic leukemia

Prognostics - Plasminogen activator inhibitor-1 used as potential marker for colorectal cancer

Prognostics - Presence of serum anti-p53 antibodies prognosticated breast cancer in Chinese patients

Prognostics - Side effects during chemotherapy predicted tumor response in advanced colorectal cancer

Prognostics - Tissue factor prognosticated recurrence of hepatocellular carcinoma in 5-year survivors

Prognostics - Treatment failure in advanced-stage cervical cancer patients predicted by risk stratification

Prostate Cancer - New data suggests combination therapy reduces adverse events in prostate cancer

Prostate Cancer - Obesity, weight gain are indicators of biochemical failure after prostatectomy

Prostate Cancer - PSA kinetics reported to predict for outcomes after radical prostatectomy

Prostate Cancer - Quality of life surveyed after radical treatment of prostate cancer

Prostate Cancer - Robotic prostatectomy outcomes reviewed

Prostate Cancer - The SDF-1/CXCR4 chemokine axis modulates prostate tumor angiogenesis

Prostate Cancer - U.S. Department of Defense awards grant for prostate cancer study

Prostate Cancer - U.S. National Cancer Institute launches a biorepository for prostate cancer

Prostate Cancer Vaccine - Allotumor mRNA-transfected dendritic cells show promise against androgen-resistant prostate cancer

Prostate Cancer Vaccine - Prostate-specific antigen DNA vaccine induces tumor protection

Prostate Cancer Vaccine - Vaccine candidates for prostate cancer with HLA-A3 supertype alleles identified

Prostate Cancer Vaccine - Vaccine therapy for prostate cancer reviewed

Proteomics - Effects of antagonists on protein-protein interactions monitored by spectroscopy

Proteomics - New findings in proteomics described

Proteomics - The alpha1 type IV collagen NC1 domain uses alpha1beta1 to target tumor vascularity

Pulmonary Medicine - Regimens combining NM-3 and docetaxel inactivate lung cancer in mice

Quality Assurance - Patient participation in medical consultations affected by physician's communication style

Radiosurgery - Benefit of radiosurgical boost for malignant gliomas resulted from selection bias

Radiotherapy - Clinical practice guidelines for re-irradiation of brain metastases suggested

Radiotherapy - High-dose rate brachytherapy and external beam radiotherapy used to treat soft tissue sarcomas

Radiotherapy - Intraoperative radiotherapy with electrons treated breast cancer with promising results

Radiotherapy - Proton beam radiotherapy compared to fractionated stereotactic radiotherapy for uveal melanomas

Radiotherapy - Radiation induced lung reactions during breast cancer therapy

Radiotherapy - Radiation therapy used to treat unresected stage I-II non-small cell lung cancer

Rectal Cancer - Recent studies add new data to rectal cancer research

Renal Cell Carcinoma - Rare case of carcinoid tumor occurred within teratoma of kidney

Sarcoma - Case of postradiotherapy intratesticular leiomyosarcoma documented

Sexual & Reproductive Health - Subfertility noted in children and young people treated for solid and hematological malignancies

Squamous Cell Carcinoma - U.S. FDA accepts Erbitux sBLA submission, grants priority review

Stem Cell Transplantation - Recent findings in stem cell transplantation provide new insights

Surgery - 5-aminolaevulinic acid-induced fluorescence cystoscopy reduced recurrence rate in stage Ta/T1 bladder cancer

Surgery - Digital flat-panel system reduced radiation dose exposure during TAE

Surgery - Hepatic resection advised for hepatocellular carcinoma with gross diaphragmatic invasion

Surgery - Partial adrenalectomy can preserve adrenocortical function in adrenal pheochromocytoma patients

Surgery - Peripheral nerve grafting did not aid erectile function recovery for prostate cancer patients

Surgery - Radical retropubic prostatectomy performed in prostate cancer patients younger than 50 years of age

Surgery - Renal cell carcinoma with tumor thrombus resected while avoiding need for cardiopulmonary bypass

Surgery - Retroperitoneal laparoscopic nephron-sparing surgery used to treat renal tumors

Surgery - Routine use of axillary dissection not recommended for ITC-positive sentinel node metastases

Surgery - Staged sentinel lymph node biopsy aided surgical planning for breast cancer

Surgery - Superextended dissection treated select, advanced gastric cancer patients

Surgical Technology - Laparoscopic colectomy effective for polyps not amenable to colonoscopic removal

Surgical Technology - Surgical curettage effective for treatment of weight-bearing areas

Tamoxifen - Overall survival not improved with letrozole after tomoxifen

Thyroid Cancer - Prognosis of thyroid cancer is not impacted by pregnancy

Tongue Cancer - Surgery preferred over brachytherapy for treatment of tongue cancer

Transplant Medicine - Surgical techniques for liver/small bowel and isolated bowel transplants outlined

Tuberculosis - Holding company obtains exclusive rights to tuberculosis test kit

Tuberculosis - Tuberculosis-related mortality is high in patients with hematologic malignancies

Tumor Suppressors - Deleted in Liver Cancer suppresses cell proliferation in hepatocellular carcinoma

Tumorigenesis - Link between tensional homeostasis and the malignant phenotype of tumors explored

Vaccine Adjuvant - Alpha-galactosylceramide acts as nasal vaccine adjuvant

Vaccine Adjuvant - Enterotoxin mucosal adjuvants induce inflammatory responses in nasal tract

Vaccine Efficacy - Vaccines with enhanced costimulation maintain high avidity memory CTL

Vaccine Vector - Adenovirus culture conditions affect immunogenicity of dendritic cells

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Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

  • Google 2010 PageRank: #2 Among Top Health News and Media Publications
  • Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
  • Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
  • Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
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