Drug Resistance
Mathematical models used to demonstrate evolutionary dynamics of chemoresistance
Published in Cancer Weekly, December 6th, 2005
According to a study from the United States, "Small molecule inhibitors target specific metabolic pathways in tumor cells and are a promising class of drugs for the treatment of cancers. The best known example is the treatment of chronic myeloid leukemia (CML) with Gleevec."
"This is a small molecule inhibitor of the Ber-Abl kinase which has been shown to drive the initiation and progression of CML. While treatment of early stage CML with Gleevec has been quite successful, later stages of the disease (blast crisis) are not successfully treated due to the...
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Source: Cancer Weekly (2005-12-06)
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