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Nanotechnology

Nanodelivery systems target primary and metastatic tumors

Published in Cancer Weekly, December 6th, 2005

Getting drugs to reach cancer cells once they have spread from the original site of the tumor in the body has continually frustrated physicians and researchers.

But now, scientists are combining a novel kind of "nanocomplex" consisting of a microscopic, lipid-based liposome and an antibody along with gene therapy in an approach they hope will both detect and target metastatic cancer cells for destruction.

Esther H. Chang, PhD, at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center in Washington, DC, and her co-workers have created a liposome nanoparticle roughly one millionth of an inch across with antibodies peppering the...

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