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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . December 13th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Cancer Risk Factors - Night work might be related to breast cancer risk

Cancer Therapy - Interferon treatment increases virotherapy for advanced hepatocellular carcinoma

Healthcare Costs - Taxane test-dose reduced cost associated with hypersensitivity reaction

Anemia - First long-term phase II study of CERA in renal patients shows control of anemia

Apoptosis - 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) induced apoptosis in pancreatic cancer

Apoptosis - Biological stimuli of neuroblastoma cell response analyzed

Apoptosis - Micromolar taxol induced cell necrosis in HeLa cells

Apoptosis - Programmed cell death pathways targeted with experimental therapeutics

Apoptosis - Role of gangliosides in fenretinide-induced apoptosis of neuroblastoma examined

Breast Cancer - New findings in the area of breast cancer detailed

Birth Defects - Fruit fly research may revolutionize the study of birth defects secondary to methotrexate use

Bladder Cancer - New brochure helps patients understand radiation therapy treatment for bladder cancer

Borna Disease - CD8 T cells require gamma interferon to clear Borna disease virus from brain

Brain Tumors - Malignant neuroblastic tumors in adolescents reviewed

Brain Tumors - Malignant transformation of intracranial epithelial cysts into squamous cell carcinoma reviewed

Breast Camcer - First patients enrolled in three breast cancer studies for Modrenal

Breast Cancer - Recent findings in breast cancer described

Breast Cancer - Anti-estrogen-resistant breast cancer cells require activated protein kinase B/Akt for growth

Breast Cancer - Breast cancer cells are prone to apoptosis and growth arrest after protein silencing

Breast Cancer - Decoy chimera prevents urokinase receptor expression and breast cancer migration

Breast Cancer - Glut-1 expression is not predictive of race-specific breast cancer recurrence

Breast Cancer - New findings in the area of breast cancer described

Breast Cancer - Recent findings in breast cancer provide new insights

Breast Cancer - Pap test for the breast may identify disease 8 years earlier than mammogram

Breast Cancer - Researchers detail new studies and findings in the area of breast cancer

Breast Cancer - Study reveals many older women refuse follow-up breast cancer tests

Breast Cancer - The distance a patient lives from a radiation therapy facility impacts breast cancer treatment

Breast Cancer Complications - Tokuhashi score predicted life expectancy of breast cancer patients with spinal metastases

Breast Cancer Diagnosis - Hormonal etiology of breast cancer may help identify reversible biomarkers

Breast Cancer Research - Minority participation in health behavior research lags behind Whites

Breast Cancer Risk Factors - Breast cancer risk is not seen with certain estrogen metabolizing polymorphisms

Breast Cancer - Researchers report details of new studies and findings in the area of breast cancer

Breast Cancer Risk Factors - Decreased risk of breast cancer is seen in long sleepers

Breast Cancer Risk Factors - Estrogen-progestin combination increases breast cancer risk

Breast Cancer Risk Factors - Further study is needed to assess toremifene for chemoprevention

Breast Cancer Risk Factors - Similarity is seen between risk of breast cancer for passive and active smokers

Breast Cancer Risk Factors - Vitamin D, calcium intakes are related to lower mammographic density

Breast Cancer Screening - Age and race are likely determinants for mammography screening in elderly women

Breast Cancer Screening - CAD system proves accurate in identifying solid breast nodules

Cancer Therapy - Reports describe recent advances in cancer therapy research

Breast Cancer Screening - Digital mammography is more accurate in premenopausal or perimenopausal women

Breast Cancer Screening - Low-cost mailings of reminders increase repeat mammography interventions

Breast Cancer Screening - Preoperative lymphoscintigraphy is a useful tool for lymphatic mapping

Breast Cancer Survival - Age is not an independent prognostic factor for breast cancer survival

Breast Cancer Survival - Early physiotherapy after breast cancer surgery improves overall quality of life

Breast Cancer Therapy - Anastrozole decreases plasma lipids during neoadjuvant therapy

Cancer Therapy - Researchers' data advance cancer therapy research

Breast Cancer Therapy - Fat necrosis is common after breast-conserving surgery

Breast Cancer Therapy - Improved quality of life is seen with surgical treatment of breast cancer in the elderly

Breast Cancer Therapy - Medicinal herb induces cell growth arrest and apoptosis in breast cancer cells

Breast Cancer Therapy - Women switched to anastrozole treatment have improved event-free survival

Business & Finance - Brachytherapy seed producer stock quoted on OTCBB

Cancer Gene Therapy - HER-2 protein expression can be inhibited in ovarian cancer cells

Cancer Therapy - Researchers' findings advance cancer therapy research

Cancer Gene Therapy - Knockdown of c-Met by small interfering RNA inhibits hepatocellular carcinoma

Cancer Gene Therapy - Papillary thyroid carcinoma after recombinant GH therapy for Turner syndrome

Cancer Gene Therapy - Zebularine has antimitogenic and chemosensitizing effects in ovarian cancer

Cancer Invasion - Runx2 transcription factor regulates cancer cell metastasis and invasion

Cancer Prevention - Reports add new data to cancer prevention research

Cancer Therapy - Researchers' work adds to cancer therapy body of knowledge

Cancer Research - AKT cancer cell pathway demonstrates an unexpected function

Cancer Research - AmpliMed research shows preliminary evidence of antitumor activity

Cancer Research - Pediatric cancer research launches new research infastructure initiative

Cancer Research - Plant gene research may lead to the development of new oncology drugs

Cancer Research - Study demonstrates XL880 is generally well tolerated

Cancer Research - Testing for transitional cell carcinoma will improve outcome of dialysis patients

Diagnostics - Researchers describe findings in diagnostics studies

Cancer Research - The role of melatonin in cancer therapy is described as compelling

Cancer Research - Vascular disrupting agents combined with antiangiogenics offer tumor strategy

Cancer Risk Factors - Carriers of death receptor 4 haplotype 626C-683C linked to increased breast cancer risk

Cancer Risk Factors - Manipulating elevated LH levels in BRCA1 mutation carriers may reduce cancer risk

Cancer Risk Factors - Radiation exposure detected in personnel performing endoscopic retrograde cholangiopancreatography

Cancer Risk Factors - Relationship between sunbed use and cutaneous melanoma in Europe assessed

Diagnostics - Researchers publish new studies and findings in the area of diagnostics

Cancer Survival - Prognostic factors and survival in familial melanoma discussed

Cancer Therapy - A specific microdomain controls phenotypic behavior of bladder cancer cells

Cancer Therapy - Advantages and disadvantages of management strategies for stage I seminoma discussed

Cancer Therapy - Anti-Helicobacter pylori therapy used to treat MALT lymphoma

Cancer Therapy - Breast cancer drug may help combat weight loss during radiation therapy

Cancer Therapy - Chemoradiotherapy improved tumor control of nasopharyngeal carcinoma

Oncology - Research in oncology provides new insights

Cancer Therapy - Continuous endostatin infusions stabilize advanced cancer cases

Cancer Therapy - Curcumin reported to suppress growth of head and neck squamous cell carcinoma

Cancer Therapy - Data from phase I trial of XL999 establishing MTD presented at cancer conference

Cancer Therapy - Decreasing cancer-suppressing protein activity increases lifespan in fruit fly model

Cancer Therapy - Epigallocatechin-3-gallate blocks photocarcinogenesis by thwarting proangiogenic activity

Cancer Therapy - High dose 3DCRT when combined with long-term androgen deprivation benefited unfavorable prostate cancer

Oncology - Researchers detail new studies and findings in the area of oncology

Cancer Therapy - High dose L-asparaginase therapy evaluated for standard risk acute lymphoblastic leukemia

Cancer Therapy - High-content screening of cytotoxic agents achieved

Cancer Therapy - Inhibition of MDM2 proposed as therapeutic strategy for neuroblastoma

Cancer Therapy - Late effects of pelvic rhabdomyosarcoma in female survivors analyzed

Cancer Therapy - Lower dose of hyperfractionated whole brain radiation delayed neurotoxicity from chemoradiation in lymphoma patients

Cancer Therapy - Macrophage migration inhibitory factor marks hypoxia-dependent chemosensitivity

Cancer Therapy - Magnesium depletion enhanced cisplatin-induced nephrotoxicity

Cancer Therapy - Management strategies of non-seminomatous germ cell tumors discussed

Cancer Therapy - Meningoceles are induced by an antitumor agent in rat fetuses

Cancer Therapy - Older women who receive pelvic irradiation may be at increased risk for pelvic fractures

Cancer Therapy - Oncolytic viral therapy approved for head and neck cancer

Cancer Therapy - One thousandth prostate cancer patient treated with IsoCord at Kuopio University Hospital

Cancer Therapy - Positive Panzem NCD phase Ib clinical trial results reported

Cancer Therapy - Promising results presented for tubulin binding agent, ENMD-1198

Cancer Therapy - Radiotherapy advised after parotidectomy for parotid area lymph node metastases from squamous cell carcinoma

Cancer Therapy - Recent studies add new data to cancer therapy research

Cancer Therapy - Study highlights needed improvements in management of women with cancer

Cancer Therapy - Thrombospondin-1 helps cyclooxygenase inhibitors fight cancer invasion

Cancer Therapy - Use of imatinib mesylate in malignant mesothelioma demonstrated limited efficacy

Cancer Therapy - Valproate activates bovine leukemia virus gene expression and induces leukemia/lymphoma regression

Cancer Therapy - [I-131]MIBG and topotecan combination therapy evaluated for neuroblastoma

Cancer Vaccine - Anti-CD3 priming generates heterogeneous antigen-specific memory CD4 T cells

Cancer Vaccine - Exosomes prepared from heat-stressed CEA-positive tumor cells induce efficient CTL response

Cancer Vaccine - Trial to study response to adjuvant therapy with melanoma cancer vaccine

Cancer Vaccine - Tumor immunology and targeted immunotherapy for CNS malignancies are reviewed

Cancer Vaccine - Tumor-targeted viral vectors are delivered by hitchhiking on antigen-specific T cells

Carcinogenesis - Natural selection in neoplastic progression of Barrett esophagus analyzed

Caregiving - Perceptions of supportive communication in Chinese patients with cancer examined

Cervical Cancer - Current treatment for premalignant cervical lesions have proven safe & effective

Cervical Cancer - Defining disease extent has potential to improve cervical cancer survival

Cervical Cancer - Laminin-5 gamma 2 chain expression aids identification of invasive cervical lesions

Cervical Cancer - Reseachers offer review of treatment options for recurrent cervical cancer

Cervical Cancer - Researchers report new drug could change management options for cervical cancer

Cervical Cancer Risk Factors - Leukocyte antigen-A polymorphism decreases risk of cervical cancer in Chinese women

Cervical Cancer Risk Factors - Women with folate deficiency showed increased risk of cervical dysplasia

Cervical Cancer Screening - 2-D gel analysis provides protein expression profiles of squamous cell carcinoma tissues

Cervical Cancer Screening - Cervical neoplasia is hard to detect due to natural cervical topography

Cervical Cancer Screening - Follow-up of abnormal Pap smears is increased by use of outreach intervention

Cervical Cancer Screening - Hybrid Capture II test proves useful for detection of high-risk HPV

Chemotherapy - Clinical and nonclinical ispinesib results reported at AACR-NCI-EORTC meeting

Chemotherapy - Efficacy of cisplatin and platinum(IV) complexes unaffected by tumor microenvironmental factors

Chemotherapy - Etoposide, cisplatin, and irinotecan triplet used to treat advanced-stage small-cell lung cancer

Chemotherapy - First-line doxorubicin and docetaxel deemed effective in patients with metastatic breast cancer

Chemotherapy - Gemcitabine and treosulfan used to treat patients with metastatic uveal melanoma

Chemotherapy - Methylene blue considered for possible use in chemotherapy

Chemotherapy - Pemetrexed plus gemcitabine did not improve overall survival in pancreatic cancer patients

Chlamydia - Male circumcision could reduce Chlamydia trachomatis infection in female partners

Clinical Trials - Drugmaker plans filing strategy for orBec

Clinical Trials - Merck makes $1 million payment on start of DNA cancer vaccine trial

Clinical Trials - Phase I clinical trial begins for anticancer small molecule drug for leukemias

Clinical Trials - Phase II cancer trials designed using total and complete response endpoints

Clinical Trials - Preclinical data demonstrate potential of prodrug technology

Clinical Trials - STIR could be used as sole imaging technique for inflammatory lesions in spine

Clinical Trials - Study data on forodesine in leukemia treatment presented at hematology meeting

Collaborations - Companies announce license, collaboration agreement for assay technology

Collaborations - South Korean firm to commercialize humanized monoclonal antibody in Asia

Collaborations - Stem cell focused company, Wayne State collaborate on prostate cancer research

Colon Cancer - Cells with MUTYH gene mutations are defective in DNA damage binding and repair

Colon Cancer - Vegetables affect the expression of genes involved in anticarcinogenic processes

Colorectal Cancer - MGMT promoter methylation proposed as mediator of field defect in sporadic colorectal cancer

Complementary & Alternative Medicine - Antitumor-promoting effects of triterpene acids from Eriobotrya japonica leaves evaluated

Complementary & Alternative Medicine - Milk thistle used in treatment and prophylaxis of cancer

Complementary & Alternative Medicine - Role of laughter in medicine reviewed

DNA Research - Cells co-opt machinery for DNA strand repair, researchers report

DNA Research - DNA hypomethylating agents improve overall response rates in myelodysplastic disorders

Dendritic Cell Vaccine - Leukemia-derived dendritic cells can be generated from blood or bone marrow cells

Depression - New findings in the area of depression detailed

Dermatology - Normal human fibroblasts bolster melanoma-induced angiogenesis

Diagnostics - Abnormal gene promoter methylation detected in paraffin-embedded sputum from patients with NSCLC

Diagnostics - Abnormal patterns of antigenic expression detected in follicular lymphoma

Diagnostics - Ameloblastomas assessed using MRI and dynamic contrast-enhanced MRI

Diagnostics - Common ultrasonographic features of pilomatricoma described

Diagnostics - Diffusion-weighted magnetic resonance imaging needed to monitor disease progression of glioma

Diagnostics - EUS-guided FNA underutilized for lymph-node staging of non-small cell lung cancer

Diagnostics - Intraoperative ultrasonography used to detect small colonic polyps

Diagnostics - L-[methyl-C-11] methionine-positron emission tomography used to monitor treatment of glioma

Diagnostics - Lowering prostate-specific antigen threshold to 2.5 ng/mL not recommended

Diagnostics - MR imaging corresponded well with clinical examination of children with diffuse pontine tumors

Diagnostics - MR imaging used to assess leukoencephalopathy in children treated for acute lymphoblastic leukemia

Diagnostics - Monopolar radiofrequency devices in minimally invasive treatment of renal cell carcinoma compared

Diagnostics - N-2 laser excited autofluorescence spectroscopy used to diagnose formalin-fixed human breast tissue

Diagnostics - New disposable biopsy and tumor marking instruments introduced

Diagnostics - PET/CT used in head and neck tumor staging

Diagnostics - Percutaneous Harlow Wood needle biopsy diagnosed spinal lesions

Diagnostics - Prostate cancer screening prevalence differed between Caucasian and low-income African-American men

Diagnostics - QMSP gene patterns in urine sediment distinguished prostate cancer patients from control subjects

Diagnostics - Raman spectroscopy used for diagnosing larynx

Diagnostics - Recent findings illuminate research in diagnostics

Diagnostics - Reporting recommendations for tumor marker prognostic studies encouraged

Diagnostics - Risk of long-time arm morbidity after sentinel node biopsy (SNB) deemed minimal

Diagnostics - SN biopsy associated with lower midterm morbidity than ALN dissection for breast cancer

Diagnostics - Technically difficult endorectal ultrasounds increase the likelihood of inaccuracy

Diagnostics - Ultrasonographic characteristics helped differentiate between metastatic and benign lymph nodes

Digestive Tract Cancer - Higher heme iron intake is associated with risk of upper digestive tract cancer

Disease Associations - Cirrhosis associated with hepatic expression of Ki-67 and p53 protein

Disease Associations - Hypophosphatemic osteomalacia associated with multiple myeloma

Disease Associations - Oral lichen planus associated with human oral carcinogenesis

Disease Associations - Risk of malignant mesothelioma increased in testicular cancer survivors

Drug Delivery - Coformulated N-octanoyl-glucosylceramide improves liposomal doxorubicin efficacy

Drug Development - AEG35156 phase I oncology trial demonstrates target response in cancer patients

Drug Development - Boronic acid bioisostere of combretastatin A-4 synthesized

Drug Development - Data from phase I trial of XL647 presented at cancer conference; therapy generally well tolerated.

Drug Development - Data suggests EOquin as a radiation sensitizer slows tumor growth

Drug Development - Endothelial cell lactosylceramide is an upstream mediator of angiogenesis

Drug Development - Mapatumumab may be the first apoptosis modulator to live up to its potential

Drug Development - Mechanism of action of multi-functional class of defense proteins discussed

Drug Development - Phase I trial of temozolomide plus O-6-benzylguanine conducted for patients with malignant glioma

Drug Development - Positive preclinical data on camptothecin compound presented

Drug Development - Study shows INGN 241 and celecoxib combination kills breast cancer cells

Drug Development - Study to define the prevalence of the molecular marker N-cadherin among a variety of tumor types

Drug Resistance - Compounds transported by MRP1 could be predicted

Drug Resistance - Disrupting thrombin-PAR1 interaction may reduce tumor drug resistance

Endocrinology - Gonadotropin-releasing hormone analogs resensitize breast cancer cells to tamoxifen

Endometrial Cancer - Epidemiological risk factors define etiology of endometrial cancer

Endometrial Cancer Screening - MRI provides better performance in endometrial carcinoma than other modalities

Finance - Cancer-focused biotech reports third-quarter revenues of $58,000

Finance - Cancer-focused company reports revenue of $3.2 million for quarter

Finance - Cancer-focused technology services company announces $15 million private placement of common stock

Finance - Carbohydrate compound developer reports net loss of $1.68 million

Finance - ComfortScan maker announces third-quarter 2005 results, revenue of $65,000

Finance - Gastrointestinal cancer drug developer records loss of $0.06 per share

Finance - Imaging company reports third quarter revenue increase of 19%

Finance - Imaging company reports third-quarter revenue of $13.4 million

Finance - Molecular therapies firm reports financial results, Colgate-Palmolive alliance

Finance - Pharmaceutical company reports $5.8 million loss in first quarter

Finance - Radiation therapy developer announces second $4.5 M institutional financing

Finance - Small molecule therapeutics developer reports third quarter net loss of $5.6 M

Finance - Telomerase-focused company reports 2005 third-quarter financial results and events

Gastroenterology - Angiopoietins are amplified in human gastric cancer

Gastroenterology - Patients with cholangiocarcinomas bear response-predicting gene mutations

Gene Research - Acute lymphocytic leukemia gene profiles reveal transformation mechanisms

Gene Research - Androgen receptor genotype might affect prostate cancer outcome

Genetics & Genomics - At least two distinct intracellular gene products required for MLV infection

Geriatrics - Lobectomy for non-small cell lung carcinoma should not be denied to elderly based on age alone

Germ Cell Tumors - Retroperitoneal germ cell tumors studied

Glioma Vaccine - EphA2 glioma-associated antigen is target for glioma vaccines

Gynecology - Somatostatin may play a role in ovarian cancer angiogenesis

HIV/AIDS Research - Resistance selection study of PPL-100 shows potentially high genetic barrier

Head & Neck Cancer - Major cytokines reflect the angiogenesis of salivary gland adenoid cystic carcinoma

Health Promotion - Broccoli sprouts boost body's ability to eliminate cancer-causing toxins

Hematology - Marine product aplidine combats overexpressed VEGF in leukemia cells

Hepatitis B Therapy - Data show chronic hepatitis B vaccine shown to be generally well tolerated

Hepatitis B Vaccine - DNA vaccine adsorbed on microparticles enhances immune responses

Hepatitis B Virus - Hepatitis B surface antigenemia and alpha-fetoprotein detected from dried blood

Hepatitis D Virus - Hepatitis delta virus RNA genome evolution occurs during long-term replication

Hepatocellular Carcinoma - Protein up-regulation is a prognostic marker of hepatocellular carcinoma

Hepatology - High methotrexate doses cause changes to functional integrity of rat liver hepatocytes

Human Papillomavirus - Modulators regulated by HPV 16 E7 oncogene in HaCaT keratinocytes are identified

Imaging - Study uses imaging to see the immune system work at a cellular level

Infectious Diseases - Recent steroid therapy increases severity of varicella infections in children with ALL

Leukemia - Higher risk of mortality among Hispanics after hematopoietic stem cell transplantation examined

Lung Cancer Mortality - Smoking interventions are needed to continue favorable trend in lung cancer mortality

Lung Cancer Risk Factors - Lung cancer risk may be associated with endogenous and extraneous estrogen

Lung Cancer Survival - Expression of nuclear estrogen receptor beta on survival differs by gender

Marketing - Drug market for superficial bladder cancer predicted to increase 10% to 2012

Medical Devices - Volume shipments of Habib4x resection device resume

Melanoma - Focal adhesion kinase downregulation affects melanoma cell viability

Melanoma Vaccine - MAGE-3 protein vaccine is not effective in patients with metastatic melanoma

Mental Health - Age and obesity alter quality of life after gynecological surgery

Mental Health - End-stage renal disease patients with strong fighting spirit are less psychologically distressed

Mental Health - Psychoactive medications linked to risk of delirium in hospitalized cancer patients

Mergers & Acquisitions - Pharma company completes acquisition of Eyetech Pharmaceuticals

Merkel Cell Cancer - Case of Merkel cell carcinoma of the auricle reported

Metastatic Melanoma - Phase II study of talabostat in stage IV melanoma complete; results promising

Multiple Myeloma - Obesity may increase the risk of multiple myeloma

Multiple Myeloma - U.S. FDA issues approvable letter for Thalomid in treatment of newly diagnosed multiple myeloma

Mutagenesis - Chromium picolinate induces mutations in L5178Y mouse lymphoma cells

Myelodysplastic Syndromes - Vidaza maker withdraws E.U. marketing authorization application

Natural Products - Resveratrol targets proangiogenic proteins in human cancer cells

Nerve Damage - Effect of patient height on paclitaxel nerve damage investigated

Neuroblastoma - New gene research may help physicians customize care for pediatric neuroblastoma and other cancers

Neurology - Midkine is overly expressed in malignant peripheral nerve sheath tumors

Neuroscience - DEC1 is not a hypoxia marker in oligodendroglial neoplasms

Non-Hodgkin Lymphoma - Promising data reported from phase II clinical trial of FavId following Rituxan

Non-Small Cell Lung Cancer - Combination therapy demonstrates 35% reduction in lung cancer tumors

Obesity Complications - Increased risk in open retropubic radical prostatectomy is observed in obese men

Oncogenesis - Murine cells model the epithelial-stromal interactions of breast cancer

Oncology - 3'-Hydroxymyosmine may be a unique urinary biomarker for the carcinogen myosmine

Oncology - Curcumin prevents breast cancer metastasis to the lungs by potentiating chemotherapy

Oncology - Early growth response gene 1 is a key regulator of heparanase in tumor cells

Oncology - Lymphangiogenesis affirms lymph node metastasis risk in non-small cell lung cancer

Oncology - Pigment epithelium-derived factor prevents VEGF expression in osteosarcoma cells

Oncology - RT inhibitors downregulate cell proliferation and restore thyrotropin signaling

Oncology - Recent findings in oncology provide new insights

Oncology - Retroviral expression screening detects oncogenes in pancreatic ductal carcinoma

Oncology - Tumor-associated macrophages interact with melanoma to drive cancer progression

Ovarian Cancer - Genomics collaboration designed to improve outcome for ovarian cancer treatment

Ovarian Cancer - U.S. NIH researcher focuses on ovarian cancer screening

Pancreatic Cancer - Drug combination may extend survival of pancreatic cancer patients

Pancreatic Cancer - Favorable 2-year survival data from phase II clinical trial of GVAX vaccine for pancreatic cancer

Papillary Thyroid Carcinoma - Prognostic factors for papillary thyroid carcinoma identified

Papillomavirus Diagnostics - Hybrid Capture II and PCR-EIA are both suitable for papillomavirus detection

Pediatric Cancer - Adverse outcomes in Childhood Cancer Survivor Study (CCSS) not associated with minority status

Pediatric Leukemia - Case of acute myeloid leukemia presenting as spinal cord compression discussed

Personnel - Cancer-focused biopharma company announces corporate changes

Personnel - Gynecological oncologist named OB-GYN chair at Stanford

Personnel - Oncology-focused drug discovery firm appoints three senior executives

Personnel - Philip Frost, MD, PhD, named interim CEO of oncology company; board initiates external search

Personnel - Provenge maker announces organizational changes: Michelle Burris and Rick Hamm take on new duties

Personnel - Russell H. Ellison, MD, MSc, named vice president of clinical development

Pharmaceutical Research - Absolute bioavailability of oral vinorelbine in patients with solid tumors determined

Pharmaceutical Research - Maximum tolerated dose of PKI166 in patients with advanced solid malignancies determined

Pharmaceutical Research - Pharmacokinetics of S-1 plus cisplatin studied in patients with advanced gastric carcinoma

Pharmaceutical Research - Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts

Pharmaceutical Research - Report shows oncology brands spend $76.8 million to launch

Pharmacokinetics - XK469 has low potential for active or toxic metabolites

Prognostics - Ocular complications in myelodysplastic syndromes can prognosticate leukemia

Prophylaxis - Use of selective estrogen receptor modulators in chemoprevention of breast cancer evaluated

Prostate Cancer - Availability of polyclonal hepsin antibody announced

Prostate Cancer - Biopharmaceutical company presents preclinical data on lead prostate cancer therapeutic candidate

Prostate Cancer - Endorectal coil improves prostate cancer imaging with 1.5 T MRI

Prostate Cancer - Outcomes from finasteride Prostate Cancer Prevention Trial discussed

Prostate Cancer - Phenoxodiol delays tumor progression in late-stage prostate cancer

Prostate Cancer - Pin1-targeted RNA interference stops angiogenesis and growth in prostate tumors

Prostate Cancer - RNA interference-directed knockdown inhibits prostate cancer

Prostate Cancer - Radiotherapeutic techniques for prostate cancer discussed

Prostate Cancer - Suicide gene expression kills PSA-expressing prostate tumor cells

Prostate Cancer Vaccine - HER-2/neu peptide vaccine prevents recurrence in high-risk prostate cancer patients

Proteomics - Downregulation of c-myc protein occurs by siRNA-mediated silencing of DNA-PKcs in HeLa cells

Quality of Life - Ambivalence over emotional expression linked to patient pain and quality of life

Quality of Life - Quality of life and illness perceptions surveyed among patients with recently diagnosed head and neck cancer

RNA Research - Mutations in microRNA transcripts are common and may have functional importance

Radiation Therapy - Low-dose radiotherapy safe and effective for lymphatic fistulas with lymphorrhea

Radiotherapy - Outcomes of I-125 radiotherapy for suspected small choroidal melanomas reviewed

Radiotherapy - Reports advance knowledge in radiotherapy research

Radiotherapy - Stereotactically guided fractionated re-irradiation used to treat recurrent glioblastoma multiforme

Rectal Cancer - Preservation of continence is feasible in resection of locally recurrent rectal cancer

Rectal Cancer - Surveillance of rectal cancer showed most recurrences occur within 5 years

Renal Cell Carcinoma - Recurrence-free survival in renal cell carcinoma patients predicted by tumor differentiation

Rheumatoid Arthritis - Golimumab shows promise in the treatment of rheumatoid arthritis in phase II trial

Salivary Gland Tumors - Cases of sublingual salivary gland tumors reviewed

Sexual & Reproductive Health - Pregnancy achieved in fertile partners of patients after prostate brachytherapy

Smoking Cessation - Pharmacotherapy for nicotine dependence is reviewed

Squamous Cell Carcinoma - Patterns of mandibular invasion by gingival squamous cell carcinoma examined

Stem Cell Research - Stem cell research developments promise innovative and cost-effective therapies

Stem Cell Transplantation - Hematopoietic allografts are safe in patients with previous fungal infections

Stem Cell Transplantation - Hematopoietic stem cell transplant patients frequently show mixed chimerism for a long period

Stem Cell Transplantation - Mesenchymal stem cells obtained after BMT or SCT originate from host tissue

Stem Cell Transplantation - Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts

Surgical Technology - Hypopharyngeal reconstruction with laryngotracheal flap deemed feasible

Surgical Technology - Neurosurgical techniques for treating adult supratentorial oligodendrogliomas described

Surgical Technology - Partial nephrectomy could still be performed using open techniques with good results

Surgical Technology - Radical resection recommended over transanal excision for T1 adenocarcinoma of the rectum

Surgical Technology - Surgical limitations of sphenoorbital meningiomas described

Surgical Technology - Techniques for renal radiofrequency ablation outlined

Thyroid Cancer - Survival of thyroid cancer patients adversely affected by lymph node metastases

Thyroid Cancer - Zactima study elicits partial response in 2 of 11 patients

Tobacco Use - A new report states that many smokers fail to quit after receiving a cancer diagnosis

Tobacco Use - Physicians, researchers need to address the issue of patients who continue to smoke after a cancer diagnosis, study argues

Tobacco Use - Smoking cessation rates increased with peer-delivered smoking counseling

Transplant Medicine -  P. aeruginosa is predominant organism causing pneumonia in orthotopic liver transplantation

Transplant Medicine - Beneficial effects of liver transplantation noted for hepatocellular carcinoma

Tubular Cancer Therapy - Radiation therapy reduces local failures, but long-term follow up is essential

Tumorigenesis - Selective evolutionary pressure drives tumor progression

Tumorigenesis - The cell-associated isoform of vascular endothelial growth factor reflects tumorigenesis

Uterine Fibroids - MRI shown to improve selection for nonsurgical treatment of uterine fibroids

Vaccine Efficacy - Neo-antigen response to keyhole limpet hemocyanin vaccines is reduced after chemotherapy

Virology - Withdrawal of lamivudine in patients can preclude hepatitis B reactivation

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