Cancer Therapy
Thrombospondin-1 helps cyclooxygenase inhibitors fight cancer invasion
Published in Cancer Weekly, December 13th, 2005
"COX inhibitors have antitumorigenic activity and increase the expression of the early growth response gene Egr-1, a tumor suppressor gene and transcription factor. In this study, we have investigated the gene regulatory and anti-invasive activity of two traditional nonsteroidal anti-inflammatory drugs (NSAID), sulindac sulfide and indomethacin," investigators in the United States report.
"These compounds inhibited tumor cell invasion and induced Egr-1 expression in lung adenocarcinoma A549 cells. Overexpression of Egr-1 reduced cellular invasion in the Matrigel...
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Source: Cancer Weekly (2005-12-13)
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