Cancer Vaccine
Anti-CD3 priming generates heterogeneous antigen-specific memory CD4 T cells
Published in Cancer Weekly, December 13th, 2005
"Anti-CD3 activation of peripheral T cells is used in adoptive immunotherapy for cancer and HIV infection, but the long-term fate of anti-CD3-primed T cells in vivo is not known. In this study, we demonstrate that anti-CD3-mediated activation of influenza hemagglutinin (HA)-specific TCR-transgenic CD4 T cells results in generation of a long-lived HA-specific memory CD4 T cell population when transferred into lymphocyte-deficient and intact mouse hosts," scientists in the United States report.
"This anti-CD3-primed memory population is indistinguishable from HA...
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Source: Cancer Weekly (2005-12-13)
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