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Chemotherapy

Gemcitabine and treosulfan used to treat patients with metastatic uveal melanoma

Published in Cancer Weekly, December 13th, 2005

Gemcitabine and treosulfan were used to treat patients with metastatic uveal melanoma.

According to recent research from Germany, "In-vitro synergy of treosulfan and gemcitabine has been observed in chemotherapy-resistant tumors. This trial investigated the efficacy of gemcitabine plus treosulfan in metastatic uveal melanoma."

"Patients received 1000 mg/m2 of gemcitabine and treosulfan at a dose of 2500 or 3000 mg/m2 in cohort 1 and 3500 or 4000 mg/m2 in cohort 2. Chemotherapy was administered on days 1 and 8 every 4 weeks. Thirty-three patients were treated, 14 in cohort 1 and 19 in cohort 2," explained A. Schmittel...

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