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Oncology

RT inhibitors downregulate cell proliferation and restore thyrotropin signaling

Published in Cancer Weekly, December 13th, 2005

Reverse transcriptase inhibitors downregulate cell proliferation and restore thyrotropin signaling and iodine uptake in thyroid anaplastic carcinoma.

"Two classes of repeated genomic elements, retrotransposons and endogenous retroviruses, encode for endogenous nontelomeric reverse transcriptase (RT), a gene that is downregulated in differentiated cells but is highly expressed in embryonic and transformed tissues.

"Two non-nucleosidic RT inhibitors, efavirenz and nevirapine, currently used in HIV treatment, reversibly downregulate tumor growth and induce differentiation in several human tumor cell models," researchers in Italy report.

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