Published in Cancer Weekly, December 13th, 2005
"Two classes of repeated genomic elements, retrotransposons and endogenous retroviruses, encode for endogenous nontelomeric reverse transcriptase (RT), a gene that is downregulated in differentiated cells but is highly expressed in embryonic and transformed tissues.
"Two non-nucleosidic RT inhibitors, efavirenz and nevirapine, currently used in HIV treatment, reversibly downregulate tumor growth and induce differentiation in several human tumor cell models," researchers in Italy report.
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