Oncology
Retroviral expression screening detects oncogenes in pancreatic ductal carcinoma
Published in Cancer Weekly, December 13th, 2005
"PDC remains one of the most intractable malignancies in humans. In order to clarify the molecular events underlying the carcinogenesis in PDC, we constructed a retroviral cDNA expression library from a PDC cell line, and used it to screen transforming genes in PDC by a focus formation assay with mouse 3T3 fibroblasts," wrote H. Kisanuki and colleagues, Jichi Medical School.
"We could obtain a total of 30 transformed cell foci in the screening, and one of the cDNA inserts harvested from such cell clones turned out to encode a...
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Source: Cancer Weekly (2005-12-13)
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