Stem Cell Transplantation

Hematopoietic stem cell transplant patients frequently show mixed chimerism for a long period

Published in Cancer Weekly, December 13th, 2005

Hematopoietic stem cell transplant patients frequently show mixed chimerism for a long period.

According to a study from Japan, "Using our recently developed human androgen receptor (HUMARA) gene-based chimerism assay, long-term chimerism was investigated in female patients who underwent hematopoietic stem cell transplantation (HCT) with cells from male donors.

"After restriction digestion of samples, we detected a small number of female-derived cells within a large population of male-derived cells, with a sensitivity from 0.1 to 0.05%."

"Chimerism was examined in four patients with myeloid malignancies: two patients with acute...

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Source: Cancer Weekly (2005-12-13)

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