Bladder Cancer
Loss of CAR expression associated with aggressive disease
Published in Cancer Weekly, December 20th, 2005
In a recent study, a group of urologists in the United States sought to determine "whether loss of coxsackie and adenovirus receptor (CAR) expression is associated with bladder cancer characteristics and clinical outcomes and with expression of p53 and E-cadherin."
"Low levels of CAR are associated with decreased efficiency of adenovirus-mediated gene transduction of bladder transitional cell carcinoma," explained K. Matsumoto and coauthors at the Baylor College of Medicine. In their study, "immunohistochemical staining for CAR and p53 was carried out on tissue...
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Source: Cancer Weekly (2005-12-20)
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