Genetics & Genomics

Effects of CpG-ODN on gene expression in formation of foam cells clarified

Published in Cancer Weekly, January 3rd, 2006

In a recent report, researchers in the People's Republic of China elucidated the effects of CpG-ODN on gene expression in formation of foam cells.

Their goal was "to investigate the effects of CpG-oligodeoxynucleotide (CpG-ODN) on the formation of macrophage foam cells and related gene expression. A gene expression profile was examined by microarray techniques, and mRNA expression was detected by reverse transcriptase polymerase chain reaction (RTPCR). The cholesterol and cholesteryl ester contents of cells were determined by high performance liquid chromatography," wrote K. Li and colleagues, Military Medical College 2.

"CD36, LPL, and Fc gamma 2b,...

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Source: Cancer Weekly (2006-01-03)

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