Lung Cancer

Polymorphism of UDP-glucuronosyltransferase 1A7 gene linked to lung cancer risk

Published in Cancer Weekly, January 3rd, 2006

Homozygous UDP-glucuronosyltransferase 1A7 (UGT1A7*3) was implicated as a risk factor for lung cancer in the Japanese population.

"UGT1A7*3 detoxifies hydroxylated benzo-(alpha)-pyrenes and 2-hydroxyamino-1-methyl-6-phenylimidazo (4,5-beta) pyridine. The purpose of this study was to evaluate whether UGTIA7 polymorphisms are risk factors for lung cancer," investigators in Japan reported.

"A total of 113 Japanese patients with lung cancer and 178 healthy individuals were enrolled in this study. Genomic DNA was isolated from leukocytes. Exon I of UGTIA7 was sequenced. Homozygous UGTIA7*3/3 was observed in 17 (15%) of patients with lung cancer, and this...

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Source: Cancer Weekly (2006-01-03)

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