Cancer Therapy
Novel thiazolidin compounds have JNK1-dependent antimitotic activity
Published in Cancer Weekly, January 3rd, 2006
In a previous study, scientists in Texas "identified two thiazolidin compounds, 5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone (MMPT) and 5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin (DBPT), that inhibit the growth of human nonsmall-cell lung and colon cancer cells independent of P-glycoprotein and p53 status."
In their subsequent study, F. Teraishi and coauthors at the University of Texas' M.D. Anderson Cancer Center "further investigated the mechanism by which these thiazolidin compounds mediate their anticancer...
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Source: Cancer Weekly (2006-01-03)
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