Apoptosis

Antiapoptotic gene is expressed and apoptosis occurs in pituitary adenomas

Published in Cancer Weekly, January 3rd, 2006

Recently published research from Italy has determined that the antiapoptotic gene seladin-1 is expressed and octreotide-induced apoptosis occurs in growth hormone-secreting and nonfunctioning pituitary adenomas.

"Seladin-1 (from selective Alzheimer disease indicator-1) is a recently discovered gene that has been found to be down-regulated in brain regions affected by Alzheimer disease. Seladin-1 effectively protects neurons against beta-amyloid-mediated toxicity and prevents apoptosis via inhibition of the activation of caspase-3, a key mediator of the apoptotic cascade," wrote P. Luciani and colleagues of the University of Florence.

"Although...

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Source: Cancer Weekly (2006-01-03)

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