Apoptosis
NF-kappa B1 and c-Rel are critical during pDC differentiation
Published in Cancer Weekly, January 3rd, 2006
"Reticuloendotheliosis viral oncogene homolog/nuclear factor of kappa light polypeptide gene enhancer in B cells 1 (Rel/NF-kappa B) activation is a ubiquitous outcome of engaging Toll-like receptors (TLRs), yet the cell-type-specific functions of this pathway in response to particular microbial signals remain poorly defined."
"Here we show that NF-kappa B1 and C-Rel, Rel/NF-kappa B proteins induced in conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) by cytosine-phosphate-guanosine (CpG) DNA, a TLR-9 ligand, serve...
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Source: Cancer Weekly (2006-01-03)
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