Apoptosis
New marine natural compounds exhibited cyclin-dependent kinase inhibitor activity
Published in Cancer Weekly, January 3rd, 2006
According to recent research from Italy, "Variolin B (VAR-B) is a natural product isolated from the sponge Kirkpatrickia variolosa, found in Antarctica. VAR-B has been shown previously to possess potent pro-apoptotic activity."
"This study was undertaken to investigate the mechanism of action of chemically synthesized VAR-B and its analogue deoxy-variolin B (dVAR-B). In different human cancer cell lines both compounds inhibited colony formation, caused cell cycle perturbations and induced apoptosis at concentrations ranging from .1 to 2 mcM. LoVo/Dx...
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Source: Cancer Weekly (2006-01-03)
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