Apoptosis
HIN-1 identified as inhibitor of cell growth and invasion
Published in Cancer Weekly, January 10th, 2006
"The HIN-1 gene encoding a small, secreted protein is silenced due to methylation in a substantial fraction of breast, prostate, lung, and pancreatic carcinomas, suggesting a potential tumor suppressor function. The receptor of HIN-1 is unknown, but ligand-binding studies indicate the presence of high-affinity cell surface HIN-1 binding on epithelial cells," investigators in the United States reported.
"Here, we report that HIN-1 is a potent inhibitor of anchorage-dependent and anchorage-independent cell growth, cell migration, and invasion. Expression of HIN-1 in synchronized cells...
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Source: Cancer Weekly (2006-01-10)
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