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Human Papillomavirus Vaccine

Adjuvanted HPV vaccine fails to protect against anogenital warts

Published in Cancer Weekly, January 10th, 2006

A randomized controlled trial of an adjuvanted human papillomavirus (HPV) type 6 L2E7 vaccine indicated it does not prevent infection of external anogenital warts.

"Cellular immunity is involved in spontaneous clearance of anogenital warts caused, most typically, by human papillomavirus (HPV) type 6 or 11, supporting the concept of therapeutic vaccination. A therapeutic vaccine composed of HPV-6 L2E7 fusion protein and AS02A adjuvant was evaluated in conjunction with conventional therapies in subjects with anogenital warts. A total of 457 subjects with anogenital warts were screened, of which 320 with HPV-6 and/or HPV-11 infection were enrolled into two double-blind,...

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