Hepatocellular Cancer

Hepatocellular carcinoma and steatohepatitis develop during valproic acid use

Published in Cancer Weekly, January 17th, 2006

According to recently published research from Japan, hepatocellular carcinoma (HCC) and nonalcoholic steatohepatitis (NASH) develop during extended valproic acid use.

"We report a case of HCC arising in NASH. The patient, a 64-year-old man, was incidentally found to have multiple tumors in the liver when admitted for pneumonia," wrote K. Sato and colleagues, Kanazawa Medical University.

"He had been obese, had been receiving a standard dose of valproic acid since clipping surgery for subarachnoid hemorrhage 17 years previously, and had not consumed any alcohol since the surgery."

The investigators observed, "Laboratory data...

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Source: Cancer Weekly (2006-01-17)

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