Breast Cancer

Human embryonic SC genes OCT4/NANOG/STELLAR/GDF3 expressed in seminoma and breast cancer

Published in Cancer Weekly, January 17th, 2006

Human embryonic stem cell genes OCT4, NANOG, STELLAR and GDF3 are expressed in seminoma and breast cancer.

According to a study from the United States, "The seminoma class of testicular germ cell tumor ((TGCT) are characterized by a morphological resemblance to primordial germ cells (PGCs) or gonocytes, and chromosome duplications at 12p.

"Recently, it was determined that human embryonic stern cells (hESCs) express genes in common with PGCs, and that three of these genes, CDF3, STELLAR, and NANOG, are located on 12p."

"The current study was designed to identify whether expression of these 12p genes were elevated in seminoma...

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Source: Cancer Weekly (2006-01-17)

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