Cancer Inhibition

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibited cancer cells

Published in Cancer Weekly, January 17th, 2006

5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) could be used to inhibit cancer cells.

"AICAR is widely used as an AMP-kinase activator, which regulates energy homeostasis and response to metabolic stress. Here, we investigated the effect of AICAR, an AMPK activator, on proliferation of various cancer cells and observed that proliferation of all the examined cell lines was significantly inhibited by AICAR treatment due to arrest in S-phase accompanied with increased expression of p21, p27, and p53 proteins and inhibition of PI3K-Akt pathway," researchers in the United States reported.

"Inhibition in in vitro growth of cancer cells was...

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Source: Cancer Weekly (2006-01-17)

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