Drug Development
10f-TDAF identified as target for antineoplastic intervention
Published in Cancer Weekly, January 24th, 2006
"A density functional theory (DFT) study is presented on the reaction mechanism of glycinamide ribonucleotide (GAR) with 10f-TDAF, which is an inhibitor designed for GAR transformylase (GAR Tfase)," scientists in the People's Republic of China reported.
"There are three different paths for this system and the results indicate that inhibitor 10f-TDAF can form a very stable intermediate with the substrate GAR or generate an imine bond with GAR by elimination of water," explained Q.A. Qiao and colleagues, Yantai Normal University.
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Source: Cancer Weekly (2006-01-24)
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