Apoptosis

Inhibited nuclear translocation overcomes apoptosis signaling defects in B-cell malignancies

Published in Cancer Weekly, January 24th, 2006

According to recent research from Germany published in the journal Clinical Cancer Research, inhibition of nuclear translocation of nuclear factor-kappa B (NF-kappa B) despite lack of functional I kappa B alpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.

"Defective apoptosis signaling is a typical feature of classic Hodgkin lymphoma, multiple myeloma, and activated B-cell-like diffuse large B-cell lymphoma. In these malignancies, the transcription factor NF-kappa B is a critical mediator of apoptosis resistance and oncogenic growth, making it an attractive therapeutic target."

"Here," wrote R.K....

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Source: Cancer Weekly (2006-01-24)

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