Leukemia
Quantification of AML1-ETO fusion transcript used to prognosticate leukemia
Published in Cancer Weekly, January 24th, 2006
"In spite of the high complete remission rate that chemotherapy achieves in acute myeloid leukemia with AML1-ETO gene rearrangement, relapse is a major cause of treatment failure in this condition," scientists in South Korea reported.
"We aimed to determine a predictor of relapse with the real-time quantitative reverse transcription polymerase chain reaction (RQ-PCR) of AML1-ETO chimeric mRNA. We serially monitored AML1-ETO fusion transcripts using RQ-PCR in 113 bone marrow or peripheral blood samples from 21 patients with AML1-ETO-positive acute...
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Source: Cancer Weekly (2006-01-24)
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