Cancer Weekly

Bone Tumors - FDG-PET used to detect bone tumors when bone scintigraphy gave negative findings

Breast Cancer - New breast magnetic resonance imaging technique endorsed

Colon Cancer - Use of artepillin C helps prevent colon cancer

Drug Resistance - Chromosomal alterations resulted in drug resistance in cancer cells

Prostate Cancer - Antiprostasome antibody titer used as supplemental prostate cancer marker

Abdominal Tumors - Abdominal position shifts detected with radiation-planning CT scans

Adverse Drug Reaction - CYP17 polymorphism may influence tamoxifen-induced hepatic steatosis

Alcoholic Hepatitis - Glycine may prevent liver cancer by impeding angiogenesis

Amputation - Sarcoma identified as leading cause of limb amputation

Analgesia - Recommendations made on safety of cancer patient-controlled analgesia

Angiology - Only nonalcoholic fraction of red wine may protect DNA from oxidative damage

Antisense Technology - Antisense oligo DNA and small interfering RNA suppress malignant cancer cell phenotypes

Apoptosis - PDCD2_C domain might not be universally associated with apoptosis

Apoptosis - Transcription inhibition proposed as potential strategy for cancer therapeutics

Astrocytomas - Fractionated stereotactic reirradiation deemed effective in gliomas

Autoimmune Disease Research - NovImmune SA files IND in the Netherlands for a human antibody that targets the CD3 antigen

Awards - Komen Tulsa affiliate awards $340,000 to local organizations to aid breast cancer fight

Barrett Esophagus - Cryoablation used to eradicate Barrett esophagus

Barrett Esophagus - Progression to high-grade dysplasia in women with Barrett esophagus is similar to men

Bladder Cancer - New findings in the area of bladder cancer described

Bladder Cancer - Published study of protein-based bladder cancer test shows 99% of malignancies found

Bladder Cancer - Researcher reports NMP22 BladderChek Test detects three times more cases of bladder cancer

Bladder Cancer - Tobacco smoking and GSTP1 polymorphism linked to bladder carcinoma

Bladder Urothelial Cancer - COX-2 protein expression related to poor outcome of bladder urothelial carcinoma

Bone Marrow - Blimp-1 is required for formation and maintenance of long-lived plasma cells

Bone Metastases - (18)FDG-PET should complement bone scintigraphy for detecting bone metastases

Brain Cancer - 3 T deemed more beneficial than 1.5 T in brain tumor magnetic resonance imaging

Brain Cancer - Anti-angiogenic therapy in pediatric neuro-oncology discussed

Brain Cancer - Atypical teratoid/rhabdoid tumors of the central nervous system identified

Brain Cancer - Infections could contribute to adult brain tumors

Brain Cancer - No link shown between mobile phone use and increased risk of glioma tumors

Brain Cancer - Recent findings in brain cancer described

Brain Metastases - Role of chemotherapy in brain metastases examined

Brain Tumor - Restoring neurogenesis might treat cognitive sequelae of brain tumor therapy

Breast Cancer - Adiponectin expression induced apoptosis in MDA-MB-231 breast cancer cells

Breast Cancer - Adjuvant breast cancer therapy needs to move away from one-fits-all mentality

Breast Cancer - Androgen receptor activity reduces cancer risk in African-American women

Breast Cancer - Calcium signaling in cancer and vitamin D examined

Breast Cancer - Clinical trial tests delivery of chemotherapy directly to breast ducts

Breast Cancer - Combined gene therapy effect revealed in syngeneic murine breast cancer models

Breast Cancer - Declines in mortality from breast cancer represent progress in disease control

Breast Cancer - Dependable social relationships predicted survival in breast carcinoma patients

Breast Cancer - High-dose chemotherapy improved survival in breast cancer patients

Breast Cancer - Identification of all sentinel nodes may reduce risk of breast cancer recurrence

Breast Cancer - Mapping for sentinel lymph node biopsy is enhanced with combined diagnostic modalities

Breast Cancer - Multicenter phase II study of MKC-1 initiated in breast cancer

Breast Cancer - Positron emission tomography for breast cancer deemed cost-effective in Canada

Breast Cancer - Prognostic factors in breast cancer change over time

Breast Cancer - Recent studies add new data to breast cancer research

Breast Cancer - Reports add new data to breast cancer research

Breast Cancer - Researchers detail new studies and findings in the area of breast cancer

Breast Cancer - Role of autoimmunity in breast cancer has broad implications in therapy target discovery

Breast Cancer - Solid-state gamma camera used to depict sentinel lymph nodes in breast cancer

Breast Cancer - Spanish-preferring Latinas experienced delays in care for breast cancer

Breast Cancer - Spleen tyrosine kinase mediated breast tumor suppression

Breast Cancer - Study examines participation in online support groups for breast cancer patients

Breast Cancer - Survival after diagnosis of breast cancer varied in Switzerland

Breast Cancer - Ultrasonography detected infraclavicular lymph node metastases in breast cancer

Breast Cancer - Unsatisfactory coping and defending mechanisms linked to risk of breast cancer

Breast Cancer - Vaginal estrogen may pose risks to patients taking new breast cancer drugs

Breast Cancer Prevention - Physician education would enhance recruitment of Asian-American women into cancer research

Breast Cancer Prevention - Review examines therapeutic value of selective estrogen receptor modulators in breast cancer

Breast Cancer Risk Factors - Breast cancer risk for Hispanic women increases with length of residency in U.S.

Breast Cancer Risk Factors - Dietary calcium/dairy consumption have slight inverse association with breast cancer risk

Breast Cancer Risk Factors - Dietary factors may influence mammographic density and breast cancer risk

Breast Cancer Risk Factors - Some foods in traditional southern diet may reduce risk of invasive breast cancer

Breast Cancer Screening - Breast cancer survival is linked more to early diagnosis than to differential treatment

Breast Cancer Survival - Extended benefit for women after 5 years of tamoxifen therapy is observed with letrozole

Breast Cancer Survival - Regional differences in breast cancer survival are explained by low diagnostic activity

Breast Cancer Therapy - Report advocates use of epirubicin for adjuvant breast cancer chemotherapy

Breast Cancer Therapy - Risk of recurrence is reduced in women treated with letrozole for breast cancer

Breast Cancer Therapy - Studies add new findings to breast cancer therapy body of knowledge

Breast Cancer Vaccine - ST6GalNAc I expression in breast cancer cells enhances tumorigenicity

Breast Disease - Body fat at young age may reduce incidence of breast disease in premenopausal women

Business & Finance - License agreement for cancer therapy satraplatin to yield $40 million in milestone payments

Business Update - Circulating tumor cells are predictive of outcome for breast cancer patients

Cancer Cell Biology - icb-1 gene expression is inducible in breast and ovarian cancer cells

Cancer Diagnostics - Current imaging algorithm and new developments in cancer diagnostics reviewed

Cancer Diagnostics - Tumor markers and (18)FDG-PET could detect tumor recurrences

Cancer Drugs - Access to drugs for cancer varied across Canada

Cancer Drugs - Cytotoxicity of MDL 72527 demonstrated in cancer cells

Cancer Drugs - Recommended dose of irinotecan in pediatric cancer patients announced

Cancer Gene Therapy - Adeno-associated virus is tumoricidal because of inhibited angiogenesis

Cancer Gene Therapy - Capsid-modified adenovirus efficiently infects tumor endothelial cells

Cancer Gene Therapy - RNA interference enhances the cisplatin sensitivity of colorectal adenocarcinoma cells

Cancer Gene Therapy - Thymidylate synthase expression is inhibited by retrovirally introduced siRNA gene

Cancer Gene Therapy - Transfected, microencapsulated cells and ifosfamide treat peritoneal cancer

Cancer Genetics - Etheno-DNA adducts may be lead markers for inflammatory cancer-prone diseases

Cancer Immunology - Interleukin-1 receptor antagonist arrests the oncological effects of interleukin-1 beta

Cancer Immunotherapy - Antibody with human sugar structures can be produced in non-mammalian host

Cancer Incidence - Extra X chromosome does not appear to increase cancer incidence, mortality in women

Cancer Inhibition - Polymeric polyphenols inhibited hematologic tumor cell lines

Cancer Prevention - Lipid peroxidation was examined as possible chemoprotective mechanism for breast cancer

Cancer Prognostics - White blood cell count, inflammation predict cancer deaths

Cancer Research - Crystal structure holds clue to Aurora kinase inhibitor's efficacy against Gleevec-resistant kinase

Cancer Research - New development enables longer survival of cells, allowing opportunity for measurement

Cancer Research - Pennsylvania may opt to give tax refund to breast, cervical cancer research

Cancer Risk Factors - BRCA1 deficiency is linked to aberrant estrogen biosynthesis associated with cancer risk

Cancer Risk Factors - Cancer incidence and mortality in UK semiconductor workers examined

Cancer Risk Factors - Inconclusive BRCA1/2 testing results create anxiety in women about cancer risk

Cancer Survivors - Divide between cancer survivorship initiatives and minorities needs bridging

Cancer Survivors - Psychosocial problems faced by adult cancer survivors analyzed

Cancer Therapy - 2C4 disrupts HER kinase signaling pathway, inhibits ovarian carcinoma cell growth

Cancer Therapy - Antiproliferative and apoptosis-inducing activity of Brucea javanica shown

Cancer Therapy - By 2020 there will be 30M people living with cancer

Cancer Therapy - Calcitriol plus NSAIDs may be potential therapy for prostate cancer

Cancer Therapy - Cancer phenotypes are suppressed through a multifunctional actin-binding protein

Cancer Therapy - Cancer treatment system non-invasively focuses heat on drug-injected region

Cancer Therapy - High-risk profiles across cancer continuum defined via multidimensional approach

Cancer Therapy - Leptosins inhibit DNA topoisomerases and induce apoptosis

Cancer Therapy - Long-term side effects of adjuvant chemotherapy reviewed

Cancer Therapy - Meisoindigo curtails angiogenic processes in chronic myelogenous leukemia cells

Cancer Therapy - Mucosectomy is a sufficient therapy for early squamous cell of the esophagus

Cancer Therapy - New findings in the area of cancer therapy described

Cancer Therapy - New research in the area of cancer therapy detailed

Cancer Therapy - Oncolytic herpes simplex virus is useful in therapy of metastatic pleural cancer

Cancer Therapy - Oral cancer plasma tumor marker identified with proteomics technology

Cancer Therapy - Polysaccharide-rich substance with antitumor activity isolated from black currant juice

Cancer Therapy - Positive early responses reported on use of HepaSphere Microsphere for liver cancer

Cancer Therapy - Preclinical data demonstrating anticancer activity of Quadramet in multiple myeloma published

Cancer Therapy - Report presents useful techniques for evaluating cancer control efforts

Cancer Therapy - Researchers' work adds to cancer therapy body of knowledge

Cancer Therapy - Study explored zebularine metabolism by aldehyde oxidase in hepatic cytosol

Cancer Therapy - UHRF1 required in tumor cell proliferation

Cancer Vaccine - Dendritic cell therapy with IFN-alpha suppresses tumors in colorectal cancer

Cancer Vaccine - Gastric cancer cell-dendritic cell hybrids induce tumor-specific T cells

Cancer Vaccine - Melanoma patient has spontaneous CTL response to MAGE-A3 peptide

Cancer Vaccine - NKT lymphocytes confer immunity via tumor-capturing dendritic cells

Cancer Vaccine - Report summarizes European Conference on Progress in Vaccination Against Cancer

Cancer Vaccines - New data illuminates research in cancer vaccines

Cancer Vaccines - Researchers detail new studies and findings in the area of cancer vaccines

Carcinogenesis - Possibility examined of thiamin deficiency as major cause of some tumors

Cervical Cancer - HPV typing from paraffin-embedded sections of cervical cancers deemed feasible

Cervical Cancer - Life sciences company inks MOU through U.S. State Department's Bio-Industry Initiative

Cervical Cancer - New data illuminates research in cervical cancer

Cervical Cancer Screening - Human papillomavirus-DNA testing may be useful to triage patients for colposcopy

Cervical Cancer Vaccine - Study examined pediatricians' intention to administer HPV vaccine

Cervical Cancer Vaccine - Transcutaneous immunization protects against HPV-induced tumors

Cervical Lymph Node Metastasis - Tc-99m-MIBI SPECT and CT used in evaluation of cervical lymph node metastasis

Chemotherapy - Researchers describe findings in chemotherapy studies

Chronic Myelogenous Leukemia - Newly discovered Bcr-abl kinase inhibitor may have therapeutic potential in CML

Clinical Trials - Dosing begun in anticancer drug trial in patients with metastatic colorectal cancer

Clinical Trials - Phase 1 clinical trial of oral heat shock protein 90 inhibitor for cancer initiated

Clinical Trials - Positive new survival findings reported from phase II and III clinical trials of orBec

Collaborations - Anticancer drug discovery collaboration signed

Collaborations - Strategic alliance agreement establishes Molecular Center of Excellence

Colon Cancer - Colon cancer survival linked to regional lymph node metastasis

Colon Cancer - Estrogen receptor-beta gene in women is associated with increased colorectal cancer risk

Colon Cancer - Sphingosine kinase 1 levels rise in colon carcinomas

Colon Cancer - Use of adjuvant chemotherapy in colon cancer differs among race, gender, and age

Colorectal Cancer - Asian-Americans have low colorectal cancer screening rates

Colorectal Cancer - Clinicopathological features predicted microsatellite instability in colorectal carcinomas

Colorectal Cancer - Colorectal cancer in colonic Crohn disease linked to DNA-aneuploidy

Colorectal Cancer - Contrast-enhanced ultrasonography used during surgery for CRC liver metastases

Colorectal Cancer - Dietary fiber intake was not correlated with lower risk of colorectal cancer

Colorectal Cancer - Extracolonic findings during colorectal cancer screening were rarely of clinical significance

Colorectal Cancer - Use of germline DNA pharmacogenetics to study colorectal tumor DNA validated

Colorectal Cancer - Use of virtual CT colectomy suggested for laparoscopic colorectal surgery

Complementary & Alternative Medicine -  Orbignya phalerata Mart activates peritoueal macrophages, which may assist in tumor treatment

Complementary & Alternative Medicine - Alternative medicine remedies might stimulate leukemic cell viability

Complementary & Alternative Medicine - Anti-inflammatory potential of Antrodia camphorata demonstrated

Complementary & Alternative Medicine - Blueberry flavonoids inhibited MMP activity in DU145 human prostate cancer cells

Complementary & Alternative Medicine - The plant compound hyperforin blocks angiogenesis

DNA Research - Positive data presented from test of alkylating anthraquinone on multiple cancer cell lines

DNA Research - Radiation sensitivity of fresh peripheral blood cells related to cancer status

Diagnostics - Angiogenic protein in nipple fluid detects breast cancer risk in women

Diagnostics - Chest CT has low sensitivity for distant metastases

Diagnostics - Clinical findings and cytology in disseminated TB can mimic anaplastic thyroid cancer

Diagnostics - Diagnostics company to supply test kits, including VScan, to China hospital in Anhui Province

Diagnostics - Extra-axillary sentinel node biopsy may help doctors manage early breast cancer

Diagnostics - Features of recurrent lung cancer cells may indicate depth of invasion in bronchial wall

Diagnostics - Interfacial properties of tissues may lead to biophysical marker of cervical cancer

Diagnostics - Intraoperative sentinel node detection enhances the staging of invasive bladder cancer

Diagnostics - Near-infrared spectroscopy is potential in vivo diagnostic of pancreatic cancer

Diagnostics - Novel approach facilitates tumor classification from gene expression profiles

Disease Associations - Acromegaly associated with increased risk of developing colonic tumors

Drug Development - Basal cell carcinoma phase I trial to be completed in first half of 2006

Drug Development - Multiple Myeloma Research Consortium selects preferred contract research organization

Drug Development - Patients with colorectal hepatic metastases may benefit from irinotecan-based adjuvant chemotherapy

Drug Development - Phase I study of EM-1421 underway targetting tumors unresponsive to conventional therapy

Drug Development - Reports describe recent advances in drug development research

Drug Development - Two antitumor agents can modify cell-bound DNA

Drug Development - Withdrawal of EMEA marketing application for rubitecan capsules announced

Drug Resistance - Transcription factors and drug resistance discussed

Ductal Carcinoma In Situ - Biological variables and prognosis of ductal carcinoma in situ discussed

Embryonal Cancer - Embryonic environment can 'normalize' tumor cells during postimplantation development

Endocrinology - Recent findings in endocrinology described

Endometrial Cancer - Estrogen exposure combined with inflammation may foster development of endometrial cancer

Endometrial Cancer - No chemoprotective effect for endometrial cancer was observed with regular aspirin use

Endometrial Cancer - Supplemental radiation therapy beneficial for stage I endometrial cancer

Enzymology - Cyclooxygenase-2 uses toll-like receptors to drive microbe-induced cancer invasion

Enzymology - Researchers publish new studies and findings in the area of enzymology

Esophageal Cancer - Appropriate staging system for esophageal carcinoma identified

Fanconi Anemia - Frog eggs help researchers understand Fanconi anemia

Finance - Cancer-focused biopharma company announces $21.6 million tax assisted financing

Finance - Genomics company reports losses of $0.10 per share