Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Apoptosis
Transcription inhibition proposed as potential strategy for cancer therapeutics
February 14th, 2006
Transcription inhibition was proposed as a potential strategy for cancer therapeutics. According to a study from the United States, "Interference with transcription triggers a stress response leading to the induction of the tumor suppressor p53. If transcription is not restored within a certain time frame cells may undergo apoptosis in a p53-dependent and independent manner." "The mechanisms by which blockage of transcription induces apoptosis may involve diminished levels of anti-apoptotic factors, inappropriate accumulation of proteins in the nucleus, accumulation of p53 at mitochondria or complications during replication. Many chemotherapeutic...
Source: Cancer Weekly (2006-02-14)
|
