Drug Resistance
Transcription factors and drug resistance discussed
Published in Cancer Weekly, February 14th, 2006
"Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of chemotherapy. Anticancer agents are known to modulate signal transduction pathways and alter expression of genes that play an important role in drug resistance," investigators in Japan reported.
"Emerging evidence suggests that the complexity of genomic response against anticancer agents arise from elaborate gene expression by multiple transcription factors," explained K. Kohno and colleagues, University of Occupational & Environmental Health.
The researchers concluded, "Here, we...
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Source: Cancer Weekly (2006-02-14)
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