Hepatocellular Cancer

Model described for nonalcoholic steatohepatitis and hepatocellular carcinoma

Published in Cancer Weekly, February 14th, 2006

According to recent research from Japan, hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice are a suitable model for nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC).

"PTEN is a multifunctional phosphatase whose substrate is phosphatidylinositol-3,4,5-triphosphate (PIP3), and it is also a ubiquitously expressed tumor suppressor gene that down-regulates phospliatidylinositol-3-kinases (PUKs). Although there are a few reports about PTEN related to hepatocellular carcinoma, the role of PTEN in the liver remains unclear."

"Therefore," wrote S. Watanabe and colleagues, Akita University, "to clarify the role of...

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Source: Cancer Weekly (2006-02-14)

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