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Bladder Cancer
Tobacco smoking and GSTP1 polymorphism linked to bladder carcinoma
February 14th, 2006
Tobacco smoking and GSTP1 polymorphism were linked to bladder carcinoma. "Although cigarette smoking is considered a major risk factor for bladder carcinoma, little is known about the interaction between metabolic genes such as glutathione-S-transferase PI and tobacco smoking in this process. GSTP1 may play a role in detoxification of tobacco-related carcinogens," scientists in the United States reported. "In this case-control study of 145 cases with bladder carcinoma (male: female=7.5:1) and 170 noncancer controls (male:female=3.7:1), the relation between genetic polymorphisms of GSTP1 and susceptibility to bladder carcinoma was investigated; and...
Source: Cancer Weekly (2006-02-14)
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