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Bladder Urothelial Cancer
COX-2 protein expression related to poor outcome of bladder urothelial carcinoma
February 14th, 2006
Cyclooxygenase-2 (COX-2) protein expression was related to poor prognosis in patients with bladder urothelial carcinoma (UC). "COX-2, a critical enzyme in the conversion of arachidonic acid to prostaglandin E2, influences the biological behavior of human tumors, being involved in carcinogenesis, tumor progression, reduced apoptosis and differentiation. The aim of the present study was to investigate the role of COX-2 protein expression in UC of the urinary bladder in relation to clinicopathological data and indices of apoptotic potential," scientists in Greece reported. "Immunohistochemistry was applied to 134 paraffin-embedded specimens of UC for...
Source: Cancer Weekly (2006-02-14)
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