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Bone Marrow
Blimp-1 is required for formation and maintenance of long-lived plasma cells
February 14th, 2006
B lymphocyte-induced maturation protein 1 (Blimp-1) is required for formation and maintenance of long-lived plasma cells. According to a study from Taiwan, "Long-lived plasma cells, residing primarily in the bone marrow, continuously secrete antibody and provide an important component of humoral memory. However, when such cells secrete autoantibodies or become transformed, they can be pathogenic." "We have shown recently that the transcriptional repressor B lymphocyte-induced maturation protein 1 is required for the formation of plasma cells. To determine what role Blimp-1 might play in maintenance of plasma cells, we generated mice in which the gene...
Source: Cancer Weekly (2006-02-14)
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