Lung Cancer

Radiation therapy and paclitaxel used to treat non-small cell lung cancer

Published in Cancer Weekly, February 14th, 2006

Thoracic radiation therapy (RT) and concomitant low-dose daily paclitaxel (PTX) could be used to treat non-small cell lung cancer (NSCLC).

"The primary objective of the current study was to determine the maximum tolerated dose of PTX that could be added daily to RT in patients with NSCLC. The secondary objective was to achieve a plasma concentration of PTX estimated to exert a radiosensitizing effect," investigators in Italy reported.

"Eighteen patients with locally advanced NSCLC were treated. Sixty Gy of RT were given in 2 Gy fractions, 5 days per week. A daily dose of PTX was delivered by 4-h i.v. infusion before RT. The initial dose level of PTX...

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Source: Cancer Weekly (2006-02-14)

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