Cancer Weekly
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Drug Resistance
Chromosomal alterations resulted in drug resistance in cancer cells
February 14th, 2006
Chromosomal alterations were purported to be the cause of drug resistance in cancer cells. "Conventional mutation-selection theories have failed to explain (i) how cancer cells become spontaneously resistant against cytotoxic drugs at rates of up to 10-3 per cell generation, orders higher than gene mutation, even in cancer cells; (ii) why resistance far exceeds a challenging drug - a state termed multidrug resistance; (iii) why resistance is associated with chromosomal alterations and proportional to their numbers; and (iv) why resistance is totally dependent on aneuploidy. We propose here that cancer-specific aneuploidy generates drug resistance via...
Source: Cancer Weekly (2006-02-14)
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