Gastric Cancer

Study compared HER2 gene amplification and HER2 protein expression

Published in Cancer Weekly, February 21st, 2006

Investigators compare HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer in a recent issue of Oncology Reports.

Scientists in Japan report, "A monoclonal antibody to HER2 protein is widely used in the treatment of patients with HER2-overexpressing breast cancer and has also been found to exhibit antitumor activity in human gastric cancer cells that overexpress HER2. The purpose of this study was to evaluate the frequency of HER2 over-expression and concordance between the results for protein expression and gene amplification in both surgical and biopsy specimens of...

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Source: Cancer Weekly (2006-02-21)

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