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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . February 28th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Bladder Cancer - Polymorphism in hGPX1 gene may be used as marker for bladder cancer recurrence

Colon Cancer - Disease-free survival after 3-year follow-up proposed as end point for colon cancer clinical trial

Glioma - Dihydroartemisinin enhanced radiosensitivity of human glioma cells

Leukemia - NS-187 proposed as novel agent for imatinib-resistant leukemia

Lung Cancer - Altered EGFR signaling implicated in genetic susceptibility to lung cancer

Acute Myeloid Leukemia - Impaired C/EBP alpha function contributes directly to AML development

Acute Myeloid Leukemia - Large population-based study examines risk for AML following Hodgkin lymphoma

Adenomatous Polyposis - Pancreas-sparing duodenectomy found effective in treating familial adenomatous polyposis

Adverse Drug Reactions - Cisplatin may trigger retinal neovascularization

Adverse Drug Reactions - Osteonecrosis of the jaw in cancer occurred after treatment with bisphosphonates

Adverse Drug Reactions - Ototoxicity in children receiving platinum chemotherapy may impact academic and social development

Apoptosis - Arsenic trioxide is a novel human neutrophil pro-apoptotic agent

Apoptosis - Data advance knowledge in apoptosis research

Apoptosis - Findings advance knowledge in apoptosis research

Apoptosis - Flavonoids inhibited cell growth and induced apoptosis in osteosarcoma cells

Apoptosis - Inhibition of P13K/PKB signaling did not directly result in apoptosis in cancer

Apoptosis - Interferon gamma-inducible protein 10 inhibits tumor angiogenesis

Apoptosis - Mechanism by which diosgenin induces apoptosis in COX-2 deficient K562 described

Apoptosis - P73 regulation may have implications for neurological disease treatment

Apoptosis - Phorbol ester-induced apoptosis in prostate cancer cells involves protein kinase C delta

Astrocytic Gliomas - TSC-22 protein expression is decreased in astrocytic gliomas

Attention Deficit Hyperactivity Disorder - Drugmaker provides update on regulatory status of Sparlon

Barrett Adenocarcinomas - Hypermethylation and loss of GPx3 expression linked to Barrett adenocarcinomas

Barrett Esophagus - Expression pattern of morphogenesis genes in Barrett esophagus studied

Bladder Cancer - Intravesical gemcitabine used to treat superficial transitional cell carcinoma

Bladder Cancer - New drug inhibited in vitro bladder cancer migration and invasion

Bladder Cancer - Research in bladder cancer provides new insights

Brain Cancer - Molecularly targeted therapy for pediatric brain tumors discussed

Breast Cancer - Breast cancer marker receives diagnostic and therapeutic patent approval

Breast Cancer - Bright-field metallography assay detects HER2 status and protein expression in breast cancer

Breast Cancer - Coffee consumption may have protective effect on breast cancer risk in premenopausal women

Breast Cancer - Data advance knowledge in breast cancer research

Breast Cancer - Decreasing risk of breast cancer is seen for women engaged in physical activity

Breast Cancer - Different subcellular localizations of ERK2 implicated in breast cancer patient survival

Breast Cancer - Endometrial thickness in breast cancer patients is not associated with tamoxifen

Breast Cancer - Findings advance knowledge in breast cancer research

Breast Cancer - Findings describe new data in breast cancer research

Breast Cancer - Findings in breast cancer provide new insights

Breast Cancer - Flow technique could simplify targeting cancer therapy

Breast Cancer - Fluorouracil-epirubicin-navelbine deemed effective in advanced breast cancer

Breast Cancer - Guidelines for intraoperative assessment of the breast detailed

Breast Cancer - HER-1 and HER-2 overexpression linked to adverse prognosis in breast cancer

Breast Cancer - Histopathology of primary breast cancer in 2005 reviewed

Breast Cancer - Infrared breast scanner hits milestone of units in service free to qualified doctors

Breast Cancer - KiSS-1 expression is increased in human breast cancer

Breast Cancer - Local cancer recurrence minimized with breast conserving therapy

Breast Cancer - Long-term treatment recommended in breast cancer patients with severe radiation-induced fibrosis

Breast Cancer - Low-density microarray useful for rapid breast tumor analysis

Breast Cancer - Macrophages can initiate breast tumor angiogenesis

Breast Cancer - Mitomycin c and capecitabine used to treat metastatic breast cancer patients

Breast Cancer - New data illuminates research in breast cancer

Breast Cancer - New findings in the area of breast cancer described

Breast Cancer - New research in the area of breast cancer detailed

Breast Cancer - Ospemifene inhibited growth of dimethylbenzanthracene-induced mammary tumors

Breast Cancer - PIK3Ca mutations correlate with gene expression and drug sensitivity

Breast Cancer - Post-pregnancy tissue changes promote breast tumor metastasis

Breast Cancer - Prediction and prevention of breast cancer discussed

Breast Cancer - Pregnancy hormones may influence rate of women with postbirth breast cancer

Breast Cancer - Protein found to control tumor growth in certain breast cancers

Breast Cancer - Recent findings illuminate research in breast cancer

Breast Cancer - Recent studies add new data to breast cancer research

Breast Cancer - Reports add new data to breast cancer research

Breast Cancer - Researchers detail new studies and findings in the area of breast cancer

Breast Cancer - Researchers report details of new studies and findings in the area of breast cancer

Breast Cancer - Researchers' findings advance breast cancer research

Breast Cancer - Skin-sparing mastectomy does not change risks to breast cancer patients

Breast Cancer - Spiritually-based breast cancer education may be more effective than secular methods

Breast Cancer - Studies describe new findings in breast cancer research

Breast Cancer - Surgery best for controlling breast cancer in older women

Breast Cancer - Surgery of liver metastases performed with low morbidity and mortality in select breast cancer patients

Breast Cancer - Survey reveals deficiencies in management of cancer treatment-induced bone loss for women

Business & Finance - Cancer drug developer posts net loss of $0.17 per share

Business & Finance - Cancer drug developer reports loss of $0.23 per share

Business & Finance - Protein, antibody developer reports net loss of $73.2M for 2005

Business & Finance - Specialty oncology company completes merger, raises $5.9 million in private financing

Cancer Diagnostics - Diagnostic criteria and clinical implications of Gleason grading discussed

Cancer Diagnostics - Genetic testing used to diagnose pheochromocytoma or functional paraganglioma

Cancer Gene Therapy - AIM2 suppresses human breast cancer cell proliferation and mammary tumor growth

Cancer Gene Therapy - Adenovirus vector is more infective for esophageal and oral carcinoma cells

Cancer Gene Therapy - p27(KIP1) prolongs cell cycle and induces apoptosis in gastric cancer cells

Cancer Gene Therapy - p53 cDNA sequence mutations are introduced by a retroviral vector

Cancer Genetics - PKCalpha expression is regulated by Elk-1 and MZF-1 in hepatocellular carcinoma

Cancer Metastasis - Study shows tumors spread when blood vessel structural cell activity is limited

Cancer Research - Genetics research may hold key to destroying cancer cells

Cancer Research - Protein suppresses growth of head and neck tumors

Cancer Research - Structure of protein essential for promoting cancer development described

Cancer Research - Tobacco settlement aids research, returns substantial dividends to Pennsylvania's economy

Cancer Risk Factors - Cancer risk does not appear related to socioeconomic variation in Norwegian women

Cancer Risk Factors - Glucose transporter polymorphisms may increase susceptibility to clear-cell renal carcinoma

Cancer Screening - Pennsylvania governor proposes giving more women access to breast and cervical cancer screening

Cancer Survivors - Pathways for psychosocial care of cancer survivors discussed

Cancer Survivors - Prevalence of risky health behaviors among cancer survivors analyzed

Cancer Therapy - Advocacy might be a valuable strategy in cancer control

Cancer Therapy - Alemtuzumab induces caspase-independent cell death in lymphocytic leukemia cells

Cancer Therapy - Alternative regimens boost the efficacy of hypericin-photodynamic therapy

Cancer Therapy - Analysis of Genasense trial confirms major efficacy variables in patients with melanoma

Cancer Therapy - Cancer organization updates to several clinical practice guidelines

Cancer Therapy - Data advance knowledge in cancer therapy research

Cancer Therapy - Docking studies shed light on folate binding in cancer therapy

Cancer Therapy - Enrollment complete in pivotal phase III trial of FavId for follicular B-cell NHL

Cancer Therapy - Findings describe new data in cancer therapy research

Cancer Therapy - Gefitinib used to treat non-small cell lung cancer

Cancer Therapy - Gemcitabine and carboplatin used to treat non-small cell lung cancer

Cancer Therapy - High-dose therapy increased complete response rate in multiple myeloma patients

Cancer Therapy - Increased role for PET imaging could improve cancer care

Cancer Therapy - Lenalidomide and thalidomide exhibit distinct pharmacological profiles

Cancer Therapy - Magnetically labeled human natural killer cells are effective against osteosarcoma cells

Cancer Therapy - Monoclonal antibody therapy for cancer treatment is focus of review

Cancer Therapy - Multicenter phase II study with MKC-1 begins

Cancer Therapy - New findings in the area of cancer therapy detailed

Cancer Therapy - No evidence of gemcitabine accumulation during weekly administration detected

Cancer Therapy - Parathyroid hormone-related protein may be a target in immunotherapy for tumors

Cancer Therapy - Phase I trial of dendritic cell vaccine in patients with colorectal cancer meets endpoint

Cancer Therapy - Recent studies add new data to cancer therapy research

Cancer Therapy - Reovirus could be developed into an effective therapy for cancer

Cancer Therapy - Reports advance knowledge in cancer therapy research

Cancer Therapy - Research add new data to cancer therapy body of knowledge

Cancer Therapy - Researchers' work adds to cancer therapy body of knowledge

Cancer Therapy - Systemic chemotherapy produces antitumor activity for metastatic hepatocellular carcinoma

Cancer Therapy - TPA plus NF-kappaB may improve the therapeutic efficacy of TPA in some myeloid leukemia patients

Cancer Therapy - The small molecule inhibitor PS1145 targets activity in prostate cancer cells

Cancer Vaccines - Antitumor immunity was induced by epitopes linked to beta2 -microglobulin

Cancer Vaccines - Cancer vaccine peptides elicit skin reaction without anaphylaxis

Cancer Vaccines - Fusion of dendritic cells with osteosarcoma activates antitumor CTLs

Cancer Vaccines - Geron clarifies license rights for cancer vaccines

Cancer Vaccines - Imiquimod enhances dendritic cell survival and promotes T-cell priming

Cancer Vaccines - Monoclonal antibodies to IGF-II inhibit IGF receptor type I signal transduction

Cancer Vaccines - OX40 costimulation and GM-CSF whole-cell vaccination overcome tolerance to tumor antigen

Cancer Vaccines - Polyoma virus-like particles elicit cytokine responses in antigen-presenting cells

Cancer Vaccines - Report describes elements of analyzing T-cell immunity

Cancer Vaccines - Reports add new data to cancer vaccines research

Cancer Vaccines - Researchers describe findings in cancer vaccines studies

Cancer Vaccines - Studies advance knowledge in cancer vaccines research

Cancer Vaccines - TRICOM vector-based cancer vaccines are focus of review

Cancer Vaccines - p43 cytokine enhances IFN-gamma production in CD4+ T cells

Carcinogenesis - Domain functions of p63 isotypes regulate different aspects of epidermal homeostasis

Cervical Cancer - HPV-18 and -45 E7 proteins can be detected in cervical carcinoma biopsies

Cervical Cancer - HPV-DNA testing may be more sensitive than repeat cytology for predicting cervical intra-epithelial neoplasia

Cervical Cancer - Laparoscopic staging enhances treatment planning for women with advanced cervical cancer

Cervical Cancer - Nude rat is orthotopic model for cervical cancer

Cervical Cancer - RT-CHT resulted in prolonged suppression of NK-cells and T-suppressor cells

Cervical Cancer - Researchers' data advance cervical cancer research

Cervical Cancer - Review examines strategies for recruiting participants into cervical cancer screening trials

Cervical Cancer - Sentinel lymph node mapping/biopsy may aid detection of early cervical cancer

Cervical Cancer - Serum hemoglobin is prognostic indicator of neoadjuvant response to chemotherapy

Cervical Cancer Risk Factors - Human leukocyte antigen-A allele alters cervical cancer risk in Chinese women

Cervical Cancer Risk Factors - Study identified human papillomavirus type for adenocarcinoma and squamous cell carcinoma

Cervical Carcinoma - Cell death occurs independent of apoptosis signals in cervical squamous cell carcinoma

Chemotherapy - Findings describe new data in chemotherapy research

Chemotherapy - Paclitaxel pharmacokinetics and effect in patients with advanced cancer studied

Childhood Cancer - Long-term outcomes of adult survivors of childhood cancer reviewed

Clinical Trials - Blood cancer patients not directed by their specialists to clinical trials, survey shows

Clinical Trials - ComfortScan maker provides update

Clinical Trials - Investigational New Drug Application filed to test safety of anticancer compound IT-101

Clinical Trials - Patient treatment begun in phase 1 clinical trial of anticancer cell-cycle inhibitor

Clinical Trials - Plans for phase 2 trial of anticancer agent in elderly poor-risk AML patients announced

Clinical Trials - TopoTarget, partner, initiate phase II clinical trial of PXD101 for T-cell lymphomas

Collaborations - Abbott Laboratories grants rights for new cancer and transplantation drug tests

Collaborations - Deal signed in Taiwan for development of Immunogene therapy for cancer indication

Collaborations - Partnership formed to develop RNAi therapeutics for childhood cancer

Collaborations - Study to evaluate research-stage diagnostic test to detect high-grade PIN

Colon Cancer - Expression of licensing factors, Cdt1 and Geminin in human colon cancer examined

Colon Cancer - New research in the area of colon cancer detailed

Colon Cancer - Open colon surgery for colon carcinomas deemed not problematic

Colon Cancer - Oral endostatin therapy does not significantly affect colon tumors

Colon Cancer - Physician recommendation may improve adherence to colorectal screening in minority women

Colon Cancer - SL4 cells used to study mechanism of hepatic metastasis of colon carcinoma cells

Colorectal Cancer - Colorectal cancers from the Middle East had different gene mutation frequencies

Colorectal Cancer - Fluorouracil-based chemotherapy does not improve survival among MSI-H patients

Colorectal Cancer - Identification of hiatus ligament needed to achieve laparoscopic total mesorectal excision

Colorectal Cancer - Nine or more lymph nodes should be examined in Dukes B colorectal cancer

Colorectal Cancer - Nitric oxide does not change colorectal cancer risk

Colorectal Cancer - Prognosis for colorectal metastases improved by major hepatectomy after portal vein embolization

Colorectal Cancer - Radical surgery used to treat T1 and T2 stage colorectal cancer patients

Colorectal Cancer - Research in colorectal cancer provides new insights

Colorectal Cancer - Risk of colorectal cancer may be reduced with higher dietary folate/vitamin B6 intake

Complementary & Alternative Medicine - A green tea extract cocktail with amino acids impedes tumor angiogenesis

Complementary & Alternative Medicine - Alternative medicine use is not uncommon following genetic testing results for BRCA1/2

Complementary & Alternative Medicine - Curcumin blocks the angiogenic capacity of endothelial cells

Complementary & Alternative Medicine - Fermented soy milk intake lowered cholesterol and TG liver buildup under oxidative stress

Contracts - Proteomics company retains Glocap Advisors as financial advisory firm

Dermatology - Report examines safety and efficacy of sunscreen products

Diagnostics - 99mTc-sestamibi scintigraphy shows myeloma activity in bone marrow

Diagnostics - I-MIBG scanning improves pheochromocytoma test accuracy

Diagnostics - Label change granted for Thyrogen

Diagnostics - Malignancy-associated changes in buccal mucosa cells may enable noninvasive screening

Diagnostics - Production agreement inked with ASKION to produce MelaFind imaging device

Diagnostics - Quantum dots detect early cervical cancer

Diagnostics - Researchers report details of new studies and findings in the area of diagnostics

Diagnostics - Serum DNA methylation markers useful in thyroid tumor diagnosis and monitoring

Diet & Nutrition - Beef tallow increases linoleic acid potency in reduction of mammary tumor metastasis

Diet & Nutrition - Single nutrition session improves short-term clinical outcomes for chronic diseases patients

Disease Associations - Fruit fly research reveals potential connection between dementia and cancer

Disease Associations - Increased risk of intestinal cancer studied in patients with Crohn disease

Doxorubicin - Doxoform suspected as a prodrug for doxazolidine

Drug Delivery - Age and tumor type influence transdermal fentanyl absorption in cancer pain patients

Drug Delivery - In vitro tests support feasibility of transdermal iontophoretic triptorelin delivery

Drug Development - Apoptosis induced by plant alkaloid sampangine in human HL-60 leukemia cells

Drug Development - Biologics license application for cervical cancer vaccine is on track

Drug Development - Dosing cycle completed on first patient in phase I trial of blood cancer drug

Drug Development - Human T cell leukemia virus type 1 protease is target for anticancer drug design

Drug Development - IND application filed for anticancer drug with nanotechnology delivery platform

Drug Development - Maryland Industrial Partnerships program approves 14 university-based research projects

Drug Development - New subsidiary to accelerate RNAi therapeutics programs

Drug Development - Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin developed

Drug Development - Pharma company initiates clinical trials of antisense drug in cancer patients

Drug Development - Pharma company receives milestone payment from Merck for ubiquitin ligases research

Drug Development - Pharmacological improvements may help KRN633 beat diseases related to pathological angiogenesis

Drug Development - Phase I trial initiated with c-Met inhibitor in patients with multiple metastatic tumors

Drug Development - Phase I trial underway of skin patch for prevention of chemo induced emesis

Drug Development - Phase II trial of Hematide initiated in patients with anemia associated with cancer

Drug Development - The new agent DN-9693 alters VEGF induction of connective tissue growth factor

Drug Resistance - New findings in the area of drug resistance described

Duodenal Cancer - Long-term results of radical resection for duodenal adenocarcinoma found positive

Endometrial Cancer - Aurora B expression used as predictor of poor prognosis in endometrial carcinoma

Endometrial Cancer - Gynecologic specialization may not affect survival in women with endometrial cancer

Endometrial Cancer - Tumor size may not independently predict recurrence in endometrial cancer

Endometriosis - Cytotoxic activity determined by endometrium may play role in development of endometriosis

Enzymology - Chymase-positive cells increase the angiogenic burden of gastric cancer

Epidemiology - Nutrition researchers dispute claims that obesity problem is exaggerated

Esophageal Adenocarcinoma - Impact of operative volume assessed after esophagectomy

Esophageal Adenocarcinoma - Neoadjuvant and adjuvant chemotherapy for esophageal adenocarcinoma discussed

Esophageal Cancer - Barrett esophagus and gastroesophageal reflux disease linked to higher mortality rates

Esophageal Cancer - Use of neoadjuvant chemoradiation in squamous cell carcinoma of the esophagus examined

Facilities - Lifeline Biotechnologies to relocate Florida facilities to Boston, Massachusetts

Finance - Breathmeter maker raises $2.9 million to continue commercialization of sensors

Finance - Cancer drug developer reports loss of $0.99 per share, provides clinical pipeline update

Finance - Cancer vaccine developer completes $3M institutional financing

Finance - Developer of radiation therapy device records $1.1 million in sales in fiscal 2006 Q1

Finance - Myeloma foundation awards over $8 million in 2005 to Multiple Myeloma Research Consortium

Finance - Oncology diagnostics-focused company reports 2005 revenues increased 26% to $68.5 million

Finance - Pharma company announces Tarceva net sales of $25 million for fourth quarter

Finance - Specialty pharma company signs definitive agreement for $65 million private financing

Gastric Cancer - Diagnostic accuracy of gastroscopy to detect gastric tumors evaluated

Gastric Cancer - ELF/TGF-beta signaling inactivated in human gastrointestinal cancer

Gastric Cancer - Glutathione S-transferase M1 gene null genotype linked to gastric cancer risk

Gastric Cancer - High CD40 expression in gastric cancer implicated in liver metastasis

Gastric Cancer - Low intra-tumor variability revealed in gastric cancer

Gastric Cancer - Older age of gastric cancer patients was not a contraindication to surgical treatment

Gastric Cancer - Polo-like kinase 1 depletion inhibits mitosis and apoptosis of gastric cancer cells

Gastric Cancer - Recent studies add new data to gastric cancer research

Gastric Cancer - Sentinel lymph node biopsy using gamma probe in gastric cancer deemed feasible

Gastrinomas - Gastrinomas associated with MEN-1 syndrome

Gastroenterology - Conserved gene regions leave gastric cancers invulnerable to gefitinib

Gastrointestinal Cancer - Study finds no association between hormone replacement therapy and GI cancer

Gene Research - CST6 modulates genes linked to breast cancer progression

Gene Therapy - Direct targeting of modified tumor cells to Fc gamma RI triggers cytotoxicity

Gene Therapy - STAT3 activation is differentially regulated in squamous cell carcinomas

Genetics & Genomics - Altered molecular genetics and gene expression contribute to kidney tumors

Genetics & Genomics - Genetic variation detection tool used on mutations associated with therapy in lung cancer

Genetics & Genomics - Genomic diagnostics company plans to meet with U.S. FDA

Genetics & Genomics - Research tools company launches program enabling institution-wide access to shRNAmir libraries

Genetics & Genomics - SNAI1, functioning as E-cadherin repressor, is implicated in gastric cancer

Germ-Cell Tumors - Follow-up advised for 2 years after first-line treatment of germ-cell tumors

Glioma - Temozolomide might benefit glioma patients with deletions of chromosomes 9p/10q

Gynecological Tumors - Hysterectomy may be best treatment option for placental site trophoblastic tumor

HIV/AIDS-Related Infection - HIV/AIDS impacts skin diseases through multifaceted mechanisms

Head & Neck Cancer - I-HDR brachytherapy and cervical dissection used to treat head and neck cancer

Head & Neck Cancer - p63 implicated as survival factor for tumor cells of head and neck cancers

Healthcare Access - Survival rates for black lung cancer patients may be linked to access to care

Hepatic Cancer - Visible light spectroscopy aided standard imaging during RF ablation of liver tumors

Hepatitis C Virus - HCV-like particles generated in different cells bind differently to target hepatoma cells

Hepatocellular Cancer - Early hepatocellular cancer screening advised for HBs antigen-positive Japanese

Hepatocellular Cancer - Growth index used as prognosticator for patients undergoing resection for hepatocellular carcinoma

Hepatocellular Cancer - Inducible nitric oxide synthase and MMP-9 promote liver cancer angiogenesis and progression

Hepatocellular Cancer - Methylation-based molecular margin analysis used in prognosis of HCC patients

Hepatocellular Cancer - Percutaneous laser ablation used to treat hepatocellular cancer

Hepatocellular Cancer - Percutaneous microwave and radiofrequency ablation used to treat hepatocellular cancer

Hepatocellular Cancer - Portal venous pressure measurement helped select optimal resection type for HCC

Hodgkin Disease - Chemotherapy alone used to treat Hodgkin disease in Indian children

Human Papillomavirus - Cervical mucosal antibodies protect against human papillomavirus 16

Imaging - Breast imaging report questioned by radiologists

Imaging - Imaging techniques visualize hepatocellular carcinoma in chronic liver disease

Imaging - Trial to compare CT colonography with barium enema, optical colonoscopy picks systems

Information Technology - Bioinformatics software developer awarded contracts with U.S. National Cancer Institute

Kaposi Sarcoma-Associated Herpesvirus - Researchers detail new studies and findings in the area of Kaposi sarcoma-associated herpesvirus

Kidney Cancer - Agency approves new treatment for gastrointestinal and kidney cancer

Laryngeal Cancer - Defining appropriate treatment method early improves survival for advanced laryngeal cancer

Leukemia - Combination of HDAC inhibitors and TRAIL used to treat leukemia

Leukemia - ETS-related gene overexpression predicts a worse outcome in acute myeloid leukemia

Leukemia - Extracellular KIT receptor mutants in leukemia respond to imatinib mesylate

Leukemia - HRQOL concerns over use of dexamethasone in pediatric leukemia addressed

Leukemia - License agreement signed to develop Fodosine for use in oncology

Leukemia - Mutant nucleophosmin predicted favorable prognosis in acute myeloid leukemia

Leukemia - New findings in leukemia described

Leukemia - Nucleophosmin gene mutations predicted favorable prognosis in leukemia

Leukemia - Reports add new data to leukemia research

Leukemia - Research add new data to leukemia body of knowledge

Leukemia - Researchers describe findings in leukemia studies

Leukemia - Studies advance knowledge in leukemia research

Liposarcoma - p53 gene alterations and reduced p14(ARF) expression linked to poor prognosis in liposarcoma

Liver Cancer - Gastrointestinal complications after radiation therapy for hepatocellular cancer analyzed

Liver Cancer - New findings in the area of liver cancer detailed

Liver Metastasis - Low-dose leucovorin and 5-fluorouracil used to treat liver metastasis

Lung Cancer - Causes for racial disparity in surgical treatment of early lung cancer evaluated

Lung Cancer - Extended resection of T4 lung cancer with invasion of the aorta justified

Lung Cancer - Maintenance/consolidation chemotherapy improved survival in lung cancer patients

Lung Cancer - Recent findings in lung cancer described

Lung Cancer - Recent findings in lung cancer provide new insights

Lung Cancer - Researchers provide details of new studies and findings in the area of lung cancer

Lung Cancer - Researchers publish new studies and findings in the area of lung cancer

Lung Cancer - Tumor cell-stromal fibroblast interaction revealed in model of human small-cell lung cancer

Lymphoma - Local tumor invasiveness was most important predictor of survival in lymphoma

Macular Degeneration - Macugen receives European regulatory marketing approval as AMD treatment

Marketing - Market report says 2006 launch of cancer vaccine to prevent human papillomavirus expected

Medical Devices - Novel microfluidic lab card facilitates rare cancer cell analysis

Medicare - Cancer organization releases coded guidelines to support U.S. CMS oncology demonstration program

Medullary Thyroid Cancer - Prophylactic thyroidectomy advised for C-cell hyperplasia

Melanoma - Biopsy type did not adversely affect locoregional/distant recurrence of melanoma

Melanoma - Data advance knowledge in melanoma research

Melanoma - Immunotherapy company may add additional trial to explore IVIg efficacy for melanoma

Melanoma - Paratumoral epidermal hyperplasia proposed as prognostic factor in melanoma

Melanoma Vaccines - Research add new data to melanoma vaccines body of knowledge

Melanoma Vaccines - Researchers' work adds to melanoma vaccines body of knowledge

Meningioma - Epidemiology of intracranial meningioma reviewed

Mergers & Acquisitions - Drug discovery company signs definitive agreement to acquire Montigen Pharmaceuticals

Mergers & Acquisitions - DrugMax acquires medical office-based oncology pharmacy in central Florida

Mergers & Acquisitions - Oncology services company to acquire ivpcare

Metaplasia - Expression of small intestinal and colonic phenotypes in intestinal metaplasia examined

Monoclonal Antibodies - VEGF inhibitors in cancer therapy are focus of review

Myeloid Leukemia - Nucleophosmin mutations linked to favorable prognosis in acute myeloid leukemia

Natural Products - Hyperforin has a direct effect on mammary tumor angiogenesis

Neoplastic Diseases - Intestinal transplantation used to treat intra-abdominal neoplastic disease

Neuroblastoma - New strategies needed for neuroblastoma patients with MYCN-amplified tumors

Non-Hodgkin Lymphoma - FDG-PET used in staging and follow-up of children with non-Hodgkin lymphoma

Oncology - Celecoxib challenges angiogenesis and bone metastasis in tumor models

Oncology - Glycochenodeoxycholate uses oxidative dysfunction to support biliary carcinogenesis

Oncology - Heat shock protein-90 inhibitors can control multiple myeloma

Oncology - Photodynamic therapy shuts down tumor angiogenesis and metastasis in cancer models

Oncology - Research in oncology provides new insights

Oncology - Researchers report details of new studies and findings in the area of oncology

Oncology - Study emphasizes women should see gynecological oncologists for ovarian cancer treatment

Oral Squamous Cell Cancer - SIP1 expression could be used to prognosticate oral squamous cell carcinomas

Osteosarcomas - Cytological differentiation in osteosarcomas examined

Osteosarcomas - Effect of ifosfamide in patients with osteosarcoma of extremity evaluated

Ovarian Cancer - Influence of surgeon experience and hospital volume on ovarian cancer outcome studied

Ovarian Cancer - Loss of COX-2 expression does not contribute to ovarian cancer malignancy

Ovarian Cancer - Oxaliplatin-resistant ovarian carcinoma cells possess unique gene expression

Ovarian Cancer - Research add new data to ovarian cancer body of knowledge

Ovarian Cancer - Researchers' work adds to ovarian cancer body of knowledge

Ovarian Cancer - Suppression of natural killer cell response mediated by the ovarian tumor marker CA125

Pancreatic Cancer - Chromosomal aberrations of ampulla of Vater and pancreatic head cancers detected

Pancreatic Cancer - Laparoscopic surgery used to treat pancreatic cancer

Pancreatic Cancer - New research in the area of pancreatic cancer detailed

Patents - Provectus receives fourth pharmaceutical patent for anticancer agents

Patient Care - Fear of pain associated with medical procedures and illnesses discussed

Personnel - California division of national cancer organization names David Veneziano to top job

Personnel - Clinical research organization adds three experts to global product development services group

Personnel - New thoracic cancer advisory board formed

Pharmaceutical Research - Cyclosporin A destroys established angiogenesis in laboratory models

Pharmaceutical Research - Phosphosulfomannan angiogenesis inhibitor analogues act variably

Pituitary Adenomas - Effect of cAMP-PKA pathway in nonfunctioning pituitary adenomas explored

Pituitary Adenomas - Shh down-regulation implicated in pathogenesis of pituitary adenomas

Pleomorphic Cancer - Caveolin-1 expression in pleomorphic carcinoma correlated with poor prognosis

Product Licensing - Molecular tests company licenses newly discovered coronavirus CoV-NL63 to bioMerieux

Prognostics - Low molecular weight heparin may improve prognosis of cancer patients

Prognostics - Presence of ITC in lymph nodes not a prognostic marker for stage I/II colorectal cancer

Prostate Cancer - Biopsy and radical prostatectomy specimen features of prostate cancer compared

Prostate Cancer - Combined androgen blockade with bicalutamide deemed cost-effective in prostate cancer

Prostate Cancer - Data show bicalutamide 150mg plus radiotherapy extends survival in locally advanced prostate cancer

Prostate Cancer - Diindolylmethane downregulates pro-survival pathway in prostate cancer

Prostate Cancer - Examination of antiestrogens as treatment for advanced prostate cancer advocated

Prostate Cancer - Feasibility of continuous infusion of epirubicin in prostate cancer assessed

Prostate Cancer - Ganglion curage in prostate cancer discussed

Prostate Cancer - Gleason scoring varied among pathologists and affected risk in prostate cancer

Prostate Cancer - High-risk black men in U.S. least likely to be screened for prostate cancer

Prostate Cancer - Influence of body size on PSA levels in men with low risk of prostate cancer studied

Prostate Cancer - Innovations in serum and urine markers in prostate cancer described

Prostate Cancer - Ixabepilone was active in patients with hormone-refractory prostate cancer

Prostate Cancer - Leuprolide acetate is available as subcutaneous extended-release injection

Prostate Cancer - Link between biochemical recurrence and interval between prostate biopsy and surgery assessed

Prostate Cancer - Omega-6 fats cause prostate tumors to grow twice as fast

Prostate Cancer - Outcome of patients with fortuitous prostate cancer analyzed

Prostate Cancer - Studies advance knowledge in prostate cancer research

Prostate Cancer - Studies describe new findings in prostate cancer research

Prostate Cancer - Therapeutic effect in prostate cancer assessed by magnetic resonance imaging

Prostate Cancer Vaccines - Provenge slows prostate cancer progression

Proteomics - Notch ligand Delta-like 4 hinders VEGF-related endothelial cell function

Proteomics - Recent findings in proteomics described

Proteomics - Researchers report details of new studies and findings in the area of proteomics

Public Health - Campaign launched raise awareness of childhood cancer in emerging countries

Quality Assurance - Results released from first-ever U.S. national study on cancer care quality

Rectal Cancer - Recent studies add new data to rectal cancer research

Rectal Cancer - Tumor-related factors were predictors of oncological outcome for rectal cancer

Renal Cell Cancer - Case of inflammatory myofibroblastic tumor associated with renal cell carcinoma

Renal Cell Cancer - Immunosuppressive acidic protein level used to detect renal cell carcinoma

Retinoblastoma - More aggressive bone marrow screening in retinoblastoma patients not recommended

Skin Cancer - Efficacy, reliability of photodynamic therapy shown for non-melanoma skin cancer

Skin Cancer - Harmful effects of sunlight outweigh benefit of vitamin D production

Soft Tissue Sarcoma - BCOR and/or an ECM-like protein implicated in pathogenesis of PNET sarcomas

Squamous Cell Carcinoma - Expression of p63 in intraepithelial neoplasia and squamous cell cancer analyzed

Squamous Cell Carcinoma - Human beta-defensin-2 participates in proliferation of transformed cervix cells

Squamous Cell Carcinoma - Pre-existing alterations exist in normal epithelium of patients with head and neck cancer

Stem Cell Research - Functional mammary gland generated from a single stem cell

Stem Cell Transplantation - HSCT feasible in infants with acute lymphoblastic leukemia

Stem Cell Transplantation - High cure rate of isolated CNS relapse by ASCT in pediatric acute lymphoblastic leukemia

Stem Cell Transplantation - IL-12 associated with reduced relapse without increased incidence of GVHD after AHSCT

Stem Cell Transplantation - Researchers provide details of new studies and findings in the area of stem cell transplantation

Stem Cell Transplantation - Small synthetic cyclic heptapeptide enhances donor bone marrow engraftment

Stem Cell Transplantation - Study examined kinetics of dendritic and T-cell chimerism in stem cell recipients

Surgical Technology - Surgical approach for placement of totally implantable access ports has high failure rate

Surgical Technology - TRS-guided prostate biopsy performed without anesthesia in 90% of study patients

Surgical Technology - Technique for open nerve-sparing radical retropubic prostatectomy described

Surgical Technology - Use of frozen sections in pediatric and adolescent surgical pathology examined

Synovial Sarcomas - Loss of p16(INK4A) expression implicated in development of synovial sarcomas

Synovial Sarcomas - Role of adjuvant therapies to treat grossly-resected synovial sarcoma discussed

T Cells - CD8+ and CD4+ T-cell tolerances can be broken

T-Cell Lymphoma - CD21 remains most reliable marker of FDCs in angioimmunoblastic T-cell lymphoma

Testicular Cancer - Guidelines on testicular cancer updated

Testicular Tumors - Retroperitoneal lymphadenectomy used to treat non-seminomatous testicular tumors

Thrombocytopenia - Recombinant factor VIIa can control bleeding caused by thrombocytopenia

Thyroid Cancer - Galectin-3 expression used as marker for papillary thyroid carcinoma

Thyroid Cancer - U.S. FDA grants fast track designation for Zactima for the treatment of thyroid cancer

Tissue Regeneration - Deer antlers may reveal role for stem cells in organ renewal

Tonsillar Carcinoma - P16(INK4A) overexpression used to predict prognosis in tonsillar carcinoma

Transplant Medicine - Findings describe new data in transplant medicine research

Tumor Staging - Accuracy of tumor staging using various imaging modalities compared

Ulcerative Colitis - European Medicines Agency CHMP recommends approval of Remicade for ulcerative colitis

Uterine Cancer - Platinum-based chemotherapy is efficacious in uterine papillary serous carcinoma

Uterine Cancer - Radiation therapy after uterine cancer surgery may have limited impact on survival

Vaccine Delivery - Dendritic cells were targeted using pH-responsive microparticle vaccine carriers

Veno-Occlusive Disease - Defibrotide shows success treating severe veno-occlusive disease

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Awards

eHealthcare Leadership 2011 Winner
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

  • Google 2010 PageRank: #2 Among Top Health News and Media Publications
  • Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
  • Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
  • Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
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