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Glioma

Dihydroartemisinin enhanced radiosensitivity of human glioma cells

Published in Cancer Weekly, February 28th, 2006

Dihydroartemisinin enhanced the radiosensitivity of human glioma cells.

"The antimalarial agent, artemisinin, also confers cancer-specific cytotoxic effects by reacting with ferrous iron atoms to form free radicals. Here, we investigated the radiosensitizing effects of dihydroartemisinin on glioma cells and assessed some possible mechanisms for these effects," scientists reported in the Journal of Cancer Research and Clinical Oncology.

"U373MG glioma cells treated with various concentrations of dihydroartemisinin plus radiation, and efficiency of radiosensitization was assessed by clonogenic survival assay. Expression and activity of...

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