Lung Cancer

Altered EGFR signaling implicated in genetic susceptibility to lung cancer

Published in Cancer Weekly, February 28th, 2006

Altered EGFR signaling was implicated in genetic susceptibility to lung cancer.

According to a study from the United States, "Somatic activating mutations in EGFR identify a subset of non-small cell lung cancer that respond to tyrosine kinase inhibitors. Acquisition of drug resistance is linked to a specific secondary somatic mutation, EGFR T790M."

"Here we describe a family with multiple cases of non-small cell lung cancer associated with germline transmission of this mutation. Four of 6 tumors analyzed showed a secondary somatic activating EGFR mutation, arising in cis with the germline EGFR mutation T790M," explained D.W. Bell and colleagues,...

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Source: Cancer Weekly (2006-02-28)

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